Infertility affects 48.5 million couples worldwide with a prevalence estimated at 3.5–16.7% in low- and middle-income countries. ART services are not accessible to the majority of these infertile couples due to the high cost of treatments. This work will unfold the landscape of available and potential ART services in LMIC.
Source: Oxford Academy
Biopsy length for diagnosis of giant cell arteritis is debated. We reviewed temporal artery biopsies from a 10-year period in Alberta to identify an ideal length. We suggest a 1.5 cm prefixation length is the optimal length for diagnosing giant cell arteritis.
Source: The Lancet
Of the 855 832 initial surgeries, 620 procedures led to a serious complication within 30 days after surgery. The study is the largest national study on carpal Tunnel Decompression to date. It provides strong evidence of serious postoperative complications.
Source: The Lancet
Abatacept was well tolerated by patients with early diffuse cutaneous systemic sclerosis. The primary endpoint was modified Rodnan Skin Score at 12 months. Clinically meaningful improvements in mRSS and other outcome measures were observed in both the abatacept and placebo groups.
Source: The Lancet
A subset of patients with COVID-19 develops a hyperinflammatory syndrome that has similarities with other hyperinflammatory disorders. We developed a six-criterion additive scale for the development of cHIs. The cHIS scale might be helpful in defining target populations for trials and immunomodulatory therapies.
Source: The Lancet
Severe COVID-19 is characterized by inflammation and coagulation in the presence of complement system activation. We aimed to explore the potential benefit and safety of selectively blocking the anaphylatoxin and complement protein C5a with the monoclonal antibody IFX-1.
Source: The Lancet
Otilimab inhibits granulocyte-macrophage colony-stimulating factor (GM-CSF) This is a key driver in immune-mediated inflammatory conditions. We aimed to evaluate the efficacy, safety, and key patient-reported outcomes related to pain in patients with active rheumatoid arthritis.
Source: The Lancet
Tocilizumab is a monoclonal antibody directed against the interleukin-6 receptor. It has been proposed to mitigate the cytokine storm syndrome associated with severe COVID-19. In this observational study, patients with the syndrome who received tocilizumab had reduced mortality.
Source: The Lancet
Hydroxychloroquine is one of several agents being evaluated in the treatment of severe acute respiratory syndrome coronavirus 2. Overall mortality was lower in the hydroxychloroquine group than in the group that did not receive hydroxychloroquine.
Source: The Lancet
Hydroxychloroquine has received negative publicity for adverse events associated with its authorization for emergency use to treat patients with COVID-19 pneumonia. Long-term use of hydroxychloroquine appears to be associated with increased cardiovascular mortality. The addition of azithromycin appears to increase the risk of heart failure and chest pain or angina.
Source: The Lancet