Pathways for the development of multiple epithelial types of intraductal papillary mucinous neoplasm of the pancreas
The intraductal papillary mucinous neoplasm of the pancreas is categorized into four distinct types. Each type is associated with specific clinicopathological features. We obtained 103 lesions of various types, including 49 gastric, 26 intestinal, 22 pancreaticobiliary. Comparative analysis was performed by targeted sequencing of 37 genes in different lesion types within each pancreas. Gastric-type low-grade lesions have a risk of progression into high-grade lesions of other types.
