Nucleic acid amplification tests on respiratory samples for the diagnosis of coronavirus infections: a systematic review and meta-analysis
Management and control of coronavirus disease 2019 (COVID-19) rely on reliable diagnostic testing. Evaluation of diagnostic test accuracy of nucleic acid amplification tests for the diagnosis of coronavirus infections. On average 10% of patients with coronavirus infections might be missed with sequencing. Real-time RT-PCR and tests targeting the N or S gene or more than one gene showed higher sensitivity. Variables affecting sensitivity and specificity can be used for test selection and developm
