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Safety and efficacy of galcanezumab in patients for whom previous migraine preventive medication from two to four categories had failed (CONQUER): a multicentre, randomised, double-blind, placebo-controlled, phase 3b trial

We aimed to assess the safety and efficacy of galcanezumab, an antibody to calcitonin gene-related peptide. The primary endpoint was the overall mean...

Neuropathology of patients with COVID-19 in Germany: a post-mortem case series

It is unclear whether severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) gains access to the CNS. We investigated the brain tissue of patien...

Monogenic variants in dystonia: an exome-wide sequencing study

Dystonia is a clinically and genetically heterogeneous condition that occurs in isolation or in combination with other movement disorders. We sequence...

Effects of intensive versus standard blood pressure control on domain-specific cognitive function: a substudy of the SPRINT randomised controlled trial

Systolic Blood Pressure Intervention Trial(SPRINT) was an open-label, multicentre, randomized controlled trial. Participants were adults 50 years or o...

Long-term follow-up from the ORATORIO trial of ocrelizumab for primary progressive multiple sclerosis: a post-hoc analysis from the ongoing open-label extension of the randomised, placebo-controlled, phase 3 trial

Time to onset of disability progression was confirmed with four measures and time to requiring a wheelchair was also analyzed. At the study end, the p...

Safety and efficacy of MD1003 (high-dose biotin) in patients with progressive multiple sclerosis (SPI2): a randomised, double-blind, placebo-controlled, phase 3 trial

Biotin (MD1003) might enhance neuronal and oligodendrocyte energetics, resulting in improved cell function, repair, or survival. MS-SPI randomised, do...

Safety and efficacy of amantadine, modafinil, and methylphenidate for fatigue in multiple sclerosis: a randomised, placebo-controlled, crossover, double-blind trial

Methylphenidate, modafinil, and amantadine are commonly prescribed medications for alleviating fatigue in multiple sclerosis. Authors: The study did n...

Genetic determinants of survival in progressive supranuclear palsy: a genome-wide association study

The genetic basis of variation in the progression of primary tauopathies has not been determined. We aimed to identify genetic determinants of surviva...

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