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Proactive Monitoring of Adalimumab Trough Concentration Associated With Increased Clinical Remission in Children With Crohn's Disease Compared With Reactive Monitoring

Proactive monitoring of drug trough concentrations and antibodies against drugs might help determine whether patients

Systematic Review and External Validation of Prediction Models Based on Symptoms and Biomarkers for Identifying Endoscopic Activity in Crohn's Disease

Endoscopic healing, an important target of treatment for Crohn's disease (CD), requires ileocolonoscopy, which is costly and burdensome. We found only...

Step-up empiric elimination diet for pediatric and adult eosinophilic esophagitis: The 2-4-6 study

Milk and wheat/gluten are the most common food triggers for eosinophilic esophagitis (EoE) Step-up diets with few food triggers can be effective in Eo...

The impact of Helicobacter pylori infection, eradication therapy and probiotic supplementation on gut microenvironment homeostasis: An open-label, randomized clinical trial

Helicobacter pylori is associated with the remodeling of gastric microbiota. Abundances of most butyrate-producing bacteria significantly decreased, w...

Efficacy of Endoscopic Resection and Selective Chemoradiotherapy for Stage I Esophageal Squamous Cell Carcinoma

Esophagectomy is the standard treatment for stage I esophageal squamous cell carcinoma. A combination of ER and selective CRT was confirmed to be a mi...

Adalimumab Monotherapy and a Combination with Azathioprine for Crohn's Disease: A Prospective, Randomized Trial

The study evaluated the efficacy of adalimumab with and without azathioprine in patients with active Crohn's disease. The rate of endoscopic improveme...

Randomized phase III study of bevacizumab plus FOLFIRI and bevacizumab plus mFOLFOX6 as first-line treatment for patients with metastatic colorectal cancer (WJOG4407G)

WJOG4407G was a randomized, open-label, phase III trial conducted in Japan. Patients with previously untreated mCRC were randomized 1:1 to receive FOL...

Efficacy and Tolerability of High- vs Low-Volume Split-Dose Bowel Cleansing Regimens for Colonoscopy: A Systematic Review and Meta-analysis

It is not clear whether approved low-volume polyethylene glycol (PEG) regimens are as effective as high-volume PEG regimens when taken in a split dose...

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