Mismatch repair status influences response to fertility-sparing treatment of endometrial cancer

Patients younger than 40 years usually present with early-stage endometrial cancer with a favorable prognosis. This study aimed to evaluate the prognostic significance of Proactive Molecular Risk. Mismatch repair status could be used as a predictive biomarker for selecting patients who could benefit from hormone therapy.

Digital Applications Targeting Medication Safety in Ambulatory High-Risk CKD Patients

The study compared the effectiveness of two digital applications designed to improve outpatient medication safety. eKidneyCare prompted patients to review medications monthly and report changes, additions, or medication problems to clinicians.

Tofacitinib as monotherapy following methotrexate withdrawal in patients with psoriatic arthritis previously treated with open-label tofacitinib plus methotrexate: a randomised, placebo-controlled substudy of OPAL Balance

Tofacitinib is an oral Janus kinase inhibitor for the treatment of psoriatic arthritis, rheumatoid arthritis, and ulcerative colitis. Flares of worsening symptoms were reported in one (1%) of 90 patients. Some patients with psoriatic arthritis are stable on tofacitinib.

Society of Surgical Oncology-American Society for Radiation Oncology consensus guideline on margins for breast-conserving surgery with whole-breast irradiation in stages I and II invasive breast cancer

The panel convenes to examine relationship between margin width and ipsilateral breast tumor recurrence. Positive margins are associated with a 2-fold increase in the risk of IBTR compared with negative margins.

Parents’ Experiences of Having a Young Child With Acute Lymphoblastic Leukemia in China

parents’ experiences are a prerequisite to developing interventions that are sensitive to the needs of children and families. Little is known about parental experiences of having a young child with acute lymphoblastic leukemia Ten parents, recruited in central China using purposive sampling, participated face-to-face. Support services to strengthen specific families' protective factors are needed. Public education and advocacy about cancer are also necessary to decrease cancer-related stigma and

Prognostic Value of C-Reactive Protein in Patients With Coronavirus 2019

An elevated serum C-reactive protein (CRP) level was observed in most patients with coronavirus disease 2019 (COVID-19). Data for patients with clinical outcomes in a designated hospital in Wuhan, China, were retrospectively collected and analyzed from 30 January 2020 to 20 February 2020.

Delay-adjusted age- and sex-specific case fatality rates for COVID-19 in South Korea: Evolution in the estimated risk of mortality throughout the epidemic

Study was to estimate delay-adjusted case fatality rates (CFRs) for COVID-19 in South Korea. Males were found to have significantly higher CFRs than females. Estimated CFRs increased substantially from age 60 years in males and from 70 years in females. CFRs converged only from mid-April 2020.

Cochrane corner: universal screening for SARS-CoV-2 infection

Most people infected with SARS-CoV-2 have mild disease with non-specific symptoms. There is an unknown proportion of infected individuals who remain asymptomatic and infectious.

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