Remote ischaemic preconditioning ameliorates anthracycline-induced cardiotoxicity and preserves mitochondrial integrity
Anthracycline-induced cardiotoxicity (AIC) is a serious adverse effect among cancer patients. The central mechanism of AIC is irreversible mitochondrial damage. Animals receiving RIPC before doxorubicin (RIPC-Doxo) had a significantly higher LVEF at Week 16 than those treated with no pretreatment (Untreated-Dxo) This was mainly due to conserved regional contractile function.

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