Lactobacillus stress protein GroEL prevents colonic inflammation
We previously showed that supernatants of Lactobacillus biofilms induced an anti-inflammatory response by affecting the secretion of macrophage-derived cytokines. In mice, rectal administration of L. reuteri GroEL (but not E. coli GroEL) inhibited all signs of hemorrhagic colitis including rectal bleeding and weight loss. GroEL, by affecting macrophage inflammatory features, deserves to be explored as an alternative to probiotics.
