Efficacy of therapeutic plasma exchange in the treatment of Penn class 3 and 4 cytokine release syndrome complicating COVID-19
Cytokine release syndrome (CRS) is a potentially severe complication of COVID-19 most commonly resulting in respiratory failure. The study was designed to determine the efficacy of therapeutic plasma exchange (TPE) in improving oxygenation and in reducing the cytokine load in a critically ill subset of patients. All patients demonstrated significant reductions in CRP, IL-6, and IL-10, and TNFα. In the majority of patients with Penn class 3 and 4 CRS complicating COVID-19, TPE demonstrated an imp
