Reverse-transcriptase polymerase chain reaction versus chest computed tomography for detecting early symptoms of COVID-19. A diagnostic accuracy systematic review and meta-analysis

Comes during the first week of its symptoms during the pandemic. Some studies have demonstrated a significant number of false-negative RT-PCR tests. It is the current gold standard diagnostic test for this virus and has sensitivity of 60-70%. The QUADAS 2 tool was used for methodological quality evaluation.

Prolonged persistence of PCR-detectable virus during an outbreak of SARS-CoV-2 in an inpatient geriatric psychiatry unit in King County, Washington

10 patients and 7 staff members with SARS-CoV-2 infection. Thirty percent of patients remained asymptomatic over the course of infection. Cough and fever were the most common symptoms.

Kinetics of Viral Clearance and Antibody Production Across Age Groups in Children with Severe Acute Respiratory Syndrome Coronavirus 2 Infection

The study looked at children tested for SARS-CoV-2 by reverse transcription (RT) polymerase chain reaction (PCR) and immunoglobulin G antibody. Median duration of viral shedding (RT-PCR positivity) was 19.5 days. The median time to reach adequate levels of neutralizing antibodies was 36 days.

Viral Load of Severe Acute Respiratory Syndrome Coronavirus 2 in Adults During the First and Second Wave of Coronavirus Disease 2019 Pandemic in Houston, Texas: The Potential of the Superspreader

In the coronavirus disease 2019 pandemic, a minority of index cases are associated with a majority of secondary cases suggesting that superspreaders could drive the pandemic. Of the 11 564 samples tested, 1319 (11.4%) were positive for SARS-CoV-2.

Evaluating a novel, highly sensitive, and quantitative reagent for detecting SARS-CoV-2 antigen

A new quantifying reagent for detecting SARS-CoV-2 antigen was developed for early and accurate detection. The sensitivity and specificity of the test were 75.7% (56/74) and 96.0% (192/200) The concordance rate in the positive group between the antigen and nucleic acid tests was 66% (66/100) It may be useful in both clinical diagnosis and in screening because it does not require special methods such as PCR.

Lidocaine versus lidocaine plus benzydamine as a topical anesthesia regimen for unsedated upper gastrointestinal endoscopy: A comparison study

Add benzydamine (B) spray to standard treatment with a lidocaine (L) spray before upper gastrointestinal endoscopy. 118 adult patients undergoing outpatient UGE were randomly assigned to receive L (n=44), LB (38) or B (n =36) before the procedure.

Endoscopic resection with hyaluronate solution for gastrointestinal lesions: systematic review and meta-analysis

There is little consensus on whether or not hyaluronate solution (HS) is beneficial for patients. Four randomized control clinical trials (585 patients) were included into the review analyses.

A prospective evaluation of iron deficiency anemia in the GI endoscopy setting: role of standard endoscopy, videocapsule endoscopy, and CT-enteroclysis

After conventional endoscopy, the cause of anemia remains unknown in up to 40% of patients. This study involved 189 patients with IDA, including 98 women and 91 men; mean (±standard deviation) age 68 years±16.6 years. Endoscopy results were positive in 144 of 189 patients (76.2%). CT-enteroclysis and VCE allowed a diagnosis in 37 of 45endoscopy-negative patients.

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