Efficacy and Safety of Intravitreal Aflibercept for Polypoidal Choroidal Vasculopathy in the PLANET Study: A Randomized Clinical Trial

Study compared intravitreal aflibercept injection (IAI) with rescue photodynamic therapy (PDT) Improvement in visual and/or functional outcomes was achieved in more than 85% of participants who were treated with IAI.

Moderators of PTSD symptom change in group cognitive behavioral therapy and group present centered therapy

Multilevel models were used to assess trajectories of symptom clusters in male veterans. Growth models showed reductions in intrusions, avoidance, negative cognition/mood, and arousal/reactivity.

Long-term follow-up from the ORATORIO trial of ocrelizumab for primary progressive multiple sclerosis: a post-hoc analysis from the ongoing open-label extension of the randomised, placebo-controlled, phase 3 trial

Time to onset of disability progression was confirmed with four measures and time to requiring a wheelchair was also analyzed. At the study end, the percentage change from baseline was lower in those who initiated oc Relzumab early than in those initially receiving placebo. But progression remains an important unmet need in multiple sclerosis.

The other face of advanced paternal age: a scoping review of its terminological, social, public health, psychological, ethical and regulatory aspects

There is a global tendency for parents to conceive children later in life. The review suggests promising avenues of research such as introducing the voice of fathers of advanced age into the research agenda. Results show that the field of APA is still in the making and that evidence is lacking to fully address the issues of APA.

Pre-emptive Short-term Nicotinamide Mononucleotide Treatment in a Mouse Model of Diabetic Nephropathy

The activation of NAD+-dependent deacetylase, Sirt1, by the administration of nicotinamide mononucleotide (NMN) ameliorates various aging-related diseases. Short-term NMN treatment mitigated mesangium expansion and foot process effacement. It also increased kidney concentrations of NAD+ and increased expression of Sirt1 and nicotinamide phosphoribosyltransferase (Nampt). Short-term NMN treatment in early-stage DN has remote renal protective effects.

The activity of rheumatology nurses in Spain

A cross-sectional study was performed in Spanish rheumatology departments. Results were based on surveys administered to nurses. 56% of the professionals had gained their experience in outpatient clinics, 35% in day hospitals, and 9% in inpatient and primary care

Progress of radiation oncology: known and unknown

Data cited in this review were obtained mainly from PubMed and Medline in English from 1999 to 2013. A larger radiation field and a higher radiation dose are not always better. Effectiveness of radiotherapy combined with molecular targeted therapy needs more data to verify.

Ethical key issues and fundamental rights in paediatric research

TEDDYNoE (Task-force in Europe for Drug Development for the Young) proposes the integration of international human rights law to develop coherent ethical recommendations on pediatric research at the European level.

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