The chronic kidney disease and acute kidney injury involvement in COVID-19 pandemic: A systematic review and meta-analysis

Currently, the SARS-CoV-2 promptly spread across China and around the world. There are controversies about whether preexisting chronic kidney disease (CKD) and acute kidney injury complications are involved in the SARS-CoV-2 pandemic. A complication of AKI and blood urea nitrogen were remarkably elevated. CRRT is applied frequently in severe COVID-19 patients than that in nonsevere patients. The risk of AKI is higher in the critical group than that in the severe group.

Effects of ACEI and ARB on COVID-19 patients: A meta-analysis

The clinical use of ACEI/ARB in patients with COVID-19 infection remains controversial. We performed a meta-analysis on the effects on disease symptoms and tests. We searched the relevant literature from Pubmed, Embase, EuropePMC, CNKI, and other databases. ACEI/ARB had a positive effect on reducing D-dimer and the number of people with fever. It had no significant effect on other laboratory tests or symptoms in patients with COVID-19.

Incidence and outcome of out-of-hospital cardiac arrests in the COVID-19 era: A systematic review and meta-analysis

The impact of COVID-19 on pre-hospital and hospital services and hence on the prevalence and outcomes of out-of-hospital cardiac arrests (OHCA) remain unclear. Review aimed to evaluate the influence of the COVID-19 pandemic on the incidence, process, and outcomes of out-of-hospital cardiac arrests. Study quality was assessed based on the Newcastle-Ottawa Scale. There was a 120% increase in OHCA events since the pandemic. Research to define optimal processes of pre-hospital care during a pandemic

Cochrane Rehabilitation and COVID-19: a rapid living systematic review 2020 by Cochrane Rehabilitation Field. Update as of October 31st, 2020

This living systematic review presents the monthly update of the second edition of the rapid living systematic review 2020 conducted by the Cochrane Rehabilitation REH-COVER Action Steering Committee. This study was to update the monthly COVID-19 and rehabilitation literature research up to October 31st, 2020. The methodology described in the second edition of the rapid living systematic review 2020 conducted by Cochrane Rehabilitation REH-COVER action was applied. Research relevant to rehabilit

The dysregulated innate immune response in severe COVID-19 pneumonia that could drive poorer outcome

The coronavirus disease 2019 (COVID-19) has peculiar characteristics and outcomes, suggesting a unique immunopathogenesis. 36 immunocompetent non-COVID-19 and 27 COVID- 19 patients with severe pneumonia were prospectively enrolled in a single center. 19 patients had lower levels of most classical inflammatory cytokines but higher plasma concentrations of CXCL10. Cytokines could represent the dysregulated immune response in severe COVID-19 patients.

The efficacy and safety of hydroxychloroquine for COVID-19 prophylaxis: A systematic review and meta-analysis of randomized trials

Populations such as healthcare workers (HCW) that are unable to practice physical distancing are at high risk of acquiring Coronavirus disease-2019 (COVID-19). Hydroxychloroquine has in vitro antiviral properties against SARS CoV-2. The current body of evidence failed to show clinical benefit for prophylactic hydroxychloroquine and showed a higher risk of adverse events when compared to placebo. The current body of evidence failed to show clinical benefit for prophylactic hydroxychloroquine and

B Cell Subsets as Sever Severity-Associated Signatures in COVID-19 Patients

SARS-CoV-2 infection represents a global health problem that has affected millions of people. The fine host immune response and its association with the disease course have not yet been fully elucidated. The severity of COVID-19 is accompanied by changes in the B cell subpopulations. These lymphocytes could serve as potential biomarkers and even active participants in the adaptive antiviral response mounted against SARS-CoV-2.

Infection and mortality of healthcare workers worldwide from COVID-19: a systematic review

To estimate COVID-19 infections and deaths in healthcare workers from a global perspective during the early phases of the pandemic. A total of 152 888 infections and 1413 deaths were reported. Infections were mainly in women and nurses, but deaths mainly in men and doctors. The reasons for gender and specialty differences require further exploration.

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