Prevalence and incidence of hepatitis C virus infection in men who have sex with men: a systematic review and meta-analysis

WHO has set targets for hepatitis C virus (HCV) elimination by 2030. We looked at studies published and listed on MEDLINE or Embase between 2000 and 2019. The pooled HCV prevalence in MSM was 3.4% and was highest in Africa and Southeast Asia.

Efficacy of surgical or endoscopic treatment of idiopathic achalasia: a systematic review and network meta-analysis

The efficacy of treatments such as Heller's myotomy and per-oral endoscopic myotomy is unknown. We searched Cochrane Central Register of Controlled Trials, MEDLINE, Embase, and Embase Classic for randomized controlled trials. POEM and LHM were superior to PD on the direct and indirect comparison.

Personalised versus standard dosimetry approach of selective internal radiation therapy in patients with locally advanced hepatocellular carcinoma (DOSISPHERE-01): a randomised, multicentre, open-label phase 2 trial

DosisPHERE-01 was a multicentre, open-label phase 2 trial done at four health-care centers in France. Patients had unresectable locally advanced hepatocellular carcinoma with at least one measurable lesion 7cm or more in size. They were given yttrium-90-loaded glass microspheres.

Extensive peritoneal lavage with saline after curative gastrectomy for gastric cancer (EXPEL): a multicentre randomised controlled trial

Early studies suggest extensive intraoperative peritoneal lavage (EIPL) might reduce the risk of recurrence. We aimed to evaluate the survival benefit of EIPL in patients with curative gastrectomy. At the third interim analysis on Aug 28, 2019, the predictive probability of. overall survival was less than 0.

Estimating the proportion of people with chronic hepatitis B virus infection eligible for hepatitis B antiviral treatment worldwide: a systematic review and meta-analysis

In 2016, of the estimated 257 million people living with chronic hepatitis B virus (HBV) infection worldwide, only a small proportion was diagnosed and treated. Of the 13 497 studies, 162 were eligible and included in our analysis. The pooled estimate of the proportion

Safety and activity of trifluridine/tipiracil and ramucirumab in previously treated advanced gastric cancer: an open-label, single-arm, phase 2 trial

The study followed patients with unresectable advanced gastric cancer or gastro-oesophageal junction adenocarcinoma. Serious treatment-related adverse events were recorded in three patients. Trifluridine/tipiracil and ramucirumab showed an acceptable safety profile and clinical activity.

Assessment of hepatic steatosis by controlled attenuation parameter using the M and XL probes: an individual patient data meta-analysis

Most research on HCV disease burden among women aged 15–49 years focuses on pregnant women. We aimed to estimate the global prevalence of viraemic HCV in 2019 among women of childbearing age. The Eastern Mediterranean region had the highest viraemic prevalence.

Global prevalence of hepatitis C virus in women of childbearing age in 2019: a modelling study

Treatment for infection with hepatitis C virus (HCV) during pregnancy has not yet been approved. Most research on HCV disease burden among women aged 15–49 years focuses on pregnant women. This analysis provides global and national estimates of HCV prevalence in all women of childbearing age. The Eastern Mediterranean region had the highest viraemic prevalence.

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