Risks of and risk factors for COVID-19 disease in people with diabetes: a cohort study of the total population of Scotland

Of the total Scottish population on March 1, 2020 (n=5 463 300), the population with diabetes was 319 349. Of these, 1082 developed fatal or critical care unit-treated COVID-19 by July 31, 2020. Overall risks were substantially elevated in those with type 1 and type 2 diabetes compared with the background population.

The effect of vitamin D supplementation on acute respiratory tract infection in older Australian adults: an analysis of data from the D-Health Trial

We used data from the D-Health Trial, a randomized, double-blind, placebo-controlled trial of vitamin D supplementation. Vitamin D supplementation did not reduce the risk of acute respiratory tract infection. It did slightly reduce the duration of symptoms, but these were small and unlikely to be clinically significant.

Trends in predominant causes of death in individuals with and without diabetes in England from 2001 to 2018: an epidemiological analysis of linked primary care records

Prevalence of diabetes has increased in the UK and other high-income countries. People with diabetes have traditionally died primarily of vascular causes. Total mortality declined by 32% in men and 31% in women with diagnosed diabetes.

Characteristics and outcomes of pregnant women with type 1 or type 2 diabetes: a 5-year national population-based cohort study

Data was collected in the first 5 years of the National Pregnancy in Diabetes audit across 172 maternity clinics in England, Wales, and the Isle of Man. Rates of preterm delivery and LGA birth weight were higher in type 1 diabetes. Maternal glycemia and BMI are the key modifiable risk factors.

Global patterns and trends in incidence and mortality of thyroid cancer in children and adolescents: a population-based study

There has been a considerable increase in thyroid cancer incidence among adults in several countries in the past three decades. Rapid increases in incidence between 1998–2002 and 2008–12 were observed in almost all countries. Incidence rates were almost always higher in girls than in boys and increased with age in both sexes.

Sofosbuvir plus ribavirin and sofosbuvir plus ledipasvir in patients with genotype 1 or 3 hepatitis C virus and severe renal impairment: a multicentre, phase 2b, non-randomised, open-label study

There is a medical need for highly effective, safe, and well-tolerated treatments for patients infected with hepatitis C virus (HCV) Eight patients had serious adverse events, none of which were treatment-related. There were no treatment-related cardiac events or clinically significant changes in echocardiographic parameters or creatinine clearance.

Global prevalence of irritable bowel syndrome according to Rome III or IV criteria: a systematic review and meta-analysis

Irritable bowel syndrome (IBS) is one of the most common functional bowel disorders. Community prevalence appears to vary widely between different countries. We did a systematic review and meta-analysis of data from all population-based studies.

Laparoscopic ileocaecal resection versus infliximab for terminal ileitis in Crohn's disease: retrospective long-term follow-up of the LIR!C trial

LIR! C trial showed laparoscopic ileocaecal resection is a cost-effective treatment for Crohn's disease. It has similar quality-of-life outcomes to treatment with infliximab, an anti-tumor necrosis factor drug.

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