Azithromycin for community treatment of suspected COVID-19 in people at increased risk of an adverse clinical course in the UK (PRINCIPLE): a randomized, controlled, open-label, adaptive platform trial

Azithromycin, an antibiotic with potential antiviral and anti-inflammatory properties, has been used to treat COVID-19. Evidence from community randomized trials is lacking. The trial had two coprimary endpoints measured within 28 days from randomization. Inappropriate use of antibiotics leads to increased antimicrobial resistance. There is evidence that azithromycin use increased during the pandemic in the UK.

The impact of coronavirus disease 2019 (COVID-19) on liver injury in China: A systematic review and meta-analysis

Evidence for the incidence and severity of liver injury in Chinese patients with coronavirus disease 2019 (COVID-19) is still controversial. Computer searches were used to obtain reports on the incidence and markers of liver injury in Chinese patients with COVID-19. Liver injury in severe patients was more common than that in non-severe patients. The severe the coronavirus infection, the higher the level of alanine aminotransfer. There is a certain risk of liver injury in Chinese patients with C

Evaluation of a virtual endoscopy simulator for training in gastrointestinal endoscopy

The GI-Mentor is a virtual reality endoscopy simulator that can distinguish between experts and beginners. A 3-week training improves the performance of beginners significantly. The training group improved its abilities on the simulator significantly

Meta-analysis: the use of carbon dioxide insufflation vs. room air insufflation for gastrointestinal endoscopy

Carbon dioxide (CO(2) insufflation has been proposed as an alternative to air insufflation to distend the lumen in gastrointestinal (GI) endoscopy. For colonoscopy, it resulted in lower postprocedural pain intensity and increased the proportion of patients without pain at 1 h and 6 h.

Virtual reality simulation training for health professions trainees in gastrointestinal endoscopy

Traditionally, training in gastrointestinal endoscopy has been based upon an apprenticeship model. Growing awareness of the need for patient safety has brought the issue of simulation-based training to the forefront.

Doxapram alleviates low SpO 2 induced by the combination of propofol and fentanyl during painless gastrointestinal endoscopy

Doxapram is a respiratory stimulant with a short half-life. The study investigated the effects of doxapram on alleviating low SpO2 induced by the combination of propofol and fentanyl during painless gastrointestinal endoscopy.

The influence of various distractions prior to upper gastrointestinal endoscopy: a prospective randomized controlled study

The study investigated the influence of distractions such as auditive and visual distractions on patients before upper gastrointestinal endoscopy. Vital signs, autonomic nervous function, the profile of mood state, and impression for upper GI endoscope were measured.

Endoscopy for acute nonvariceal upper gastrointestinal tract hemorrhage: is sooner better? A systematic review

Early endoscopy has been advocated for its ability to achieve a prompt diagnosis, risk stratification, and therapeutic hemostasis. Most included studies found to suffer from 1 or more potentially significant methodologic shortcomings.

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