Early use of double-guidewire technique to facilitate selective bile duct cannulation: the multicenter randomized controlled EDUCATION trial

There are no guidelines for the timing of conversion to a double-guidewire technique to facilitate selective bile duct cannulation and reduce post-endoscopic retrograde cholangiopancreatography pancreatitis (PEP) A multicenter prospective randomized controlled trial included 274 patients with a naive papilla

Therapeutic success with bismuth-containing sequential and quadruple regimens in Helicobacter pylori eradication

The success rate of Helicobacter pylori eradication with classical triple therapy is gradually declining. In this study, OTMB and OA+OCMB were significantly superior to the triple therapy and succeeded to reach the eradication

Endoscopic sphincterotomy for common bile duct stones in younger patients

The median observation time after endoscopic sphincterotomy was 27.1 months. Cholecystectomy was not needed in 27 patients, of whom 23 had gallbladder stones.

Efficacy of Ramucirumab Versus Sorafenib as Subsequent Treatment for Hepatocellular Carcinoma

The study examined the therapeutic efficacy of ramucirumab compared with that of sorafenib as subsequent systemic therapy for patients with HCC. The PFS was significantly longer in the ramucirumab group than in the sorafenib group. T

Resource Utilization and Outcomes in Isolated Low-Grade Renal Trauma at a Level 1 Trauma Center

The study examined admission and transfer patterns of isolated low-grade renal trauma given the lack of evidenced-based guidelines. All patients were discharged alive and the majority (94%) was discharged home

Is perioperative chemotherapy recommended in childhood and adolescent patients with synovial sarcoma? A systematic review

Synovial sarcoma is the most common soft tissue sarcomas among childhood and adolescents. Surgical resection with an R0 margin alone was recommended. Perioperative chemotherapy did not have a significant effect on survival.

Dilated cardiomyopathy-linked heat shock protein family D member 1 mutations cause up-regulation of reactive oxygen species and autophagy through mitochondrial dysfunction

During heart failure, levels of circulatory heat shock protein family D member 1 increase. Mutations in HSPD1 cause mitochondrial dysfunction and induced mitophagy.

Modified Buried Vertical Mattress Suture Versus Buried Intradermal Suture: A Prospective Split-Scar Study

Modified buried vertical mattress suture (MBVMS) is believed to provide excellent outcomes by relieving tension on wound edges. The MBVMS provided significantly increased wound eversion immediately, postoperatively, and improved aesthetic outcomes at the end of the 3-month follow-up period.

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