The efficacy of a pectin-based raft-forming anti-reflux agent in endoscopy-negative reflux disease

Aflurax reduces heartburn in patients with endoscopy-negative gastro-oesophageal reflux disease (GORD) Patients with GORD have mainly postprandial reflux and low total acid exposure. No further treatment effect was found on day 29.

Mercaptopurine versus placebo to prevent recurrence of Crohn's disease after surgical resection (TOPPIC): a multicentre, double-blind, randomised controlled trial

Up to 60% of patients with Crohn's disease need intestinal resection within the first 10 years of diagnosis. We investigated whether mercaptopurine can prevent or delay postoperative clinical recurrence.

The ASGE guidelines for the appropriate use of colonoscopy in an open access system

In Italy, the rate of colonoscopies performed for generally not indicated reasons is high, particularly among examinations not requested by a gastroenterologist.

Evaluation of a virtual endoscopy simulator for training in gastrointestinal endoscopy

The GI-Mentor is a virtual reality endoscopy simulator that can distinguish between experts and beginners. A 3-week training improves the performance of beginners significantly.

Gastroenterologist-administered propofol versus meperidine and midazolam for advanced upper endoscopy: a prospective, randomized trial

Propofol is increasingly used for gastrointestinal endoscopy because of its rapid recovery profile. There have been no prospective, randomized comparison of gastroenterologist-administered propofol to meperidine and midazolam for endoscopic retrograde cholangiopancreatography and endoscopic ultrasonography.

Surgical outcomes of glansectomy and split thickness skin graft reconstruction for localized penile cancer

Authors report outcomes of glossectomy and split-thickness skin graft reconstruction in a consecutive series of penile cancers. 34 patients were enrolled. 1-year recurrence free-survival (RFS) was 88.2%. 1-y cancer-specific ( CSS) and overall survival (OS) resulted in 91.2% in both cases.

Benefit of surgical resection of distant metastasis in soft tissue sarcoma: a systematic review

Metastasectomy can be offered for malignant soft tissue tumors with distant metastases. The median survival period after metastasectomy ranged from 9.6 to 39.6 months. 5-year survival rate ranged from 8 to 52% and the complication rate was 7.3 to 25%.

Disruption of actin dynamics regulated by Rho effector mDia1 attenuates pressure overload-induced cardiac hypertrophic responses and exacerbates dysfunction

Cardiac hypertrophy is a compensatory response to pressure overload leading to heart failure. We identified the pivotal roles of the mammalian homolog of Drosophila diaphanous (mDia) 1, a Rho-effector molecule, in pressure overload-induced ventricular hyperTrophy.

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