Use of Reflectance Confocal Microscopy to Predict Treatment Efficacy in Café Au Lait Macules

Multiple lasers have been used for the treatment of café au lait macules with various results. Objective tools to predict the therapeutic efficacy of CALMs treatment is lacking

Tele-Ophthalmology for Age-Related Macular Degeneration and Diabetic Retinopathy Screening: A Systematic Review and Meta-Analysis

Only randomized controlled trials were included in this systematic review and meta-analysis. Tele-ophthalmology had a 14% higher odds to detect disease than traditional examination.

Physiological clearance of amyloid-beta by the kidney and its therapeutic potential for Alzheimer’s disease

Amyloid-β (Aβ) accumulation in the brain is a pivotal event in the pathogenesis of Alzheimer's disease (AD) The kidney is thought to be responsible for Aβ clearance, but direct evidence is lacking. Unilateral nephrectomy increased brain Aβ deposition and aggravated AD pathologies.

Association of serum neurofilament light chain levels with clinicopathology of chronic inflammatory demyelinating polyneuropathy, including NF155 reactive patients

Serum neurofilament light chains (NfLs) serve as a biomarker of axonal damage in patients with chronic inflammatory demyelinating polyneuropathy. Serum NFL levels were significantly higher in people with CIDP than in healthy individuals. Serum NFL correlated with pathological indices of axonal degeneration and may serve as a biomarker that reflects active axonal damage of CIDP.

Distinct microRNA profiles for complete hydatidiform moles at risk of malignant progression

MicroRNAs are small non-coding RNAs with important regulatory functions. Little is known about the role of microRNAs in premalignant disease. The study aimed to investigate possible differences in microRNA expression between moles progressing. miR-181 family members may be prognostic biomarkers for predicting gestational trophoblastic neoplasia risk.

Identification of Patients with CKD in Medical Databases

Six different algorithms are used to identify CKD in population-based medical databases. The hospital-diagnosed algorithm yielded markedly lower CKD prevalence but a much higher 1-year mortality rate. Despite these differences, laboratory-based algorithms produce cohorts with similar prognoses.

2017 European League Against Rheumatism/American College of Rheumatology classification criteria for adult and juvenile idiopathic inflammatory myopathies and their major subgroups

Data were collected from 47 rheumatology, dermatology, neurology, and pediatric clinics worldwide. A probability cut-off of 55%, corresponding to a score of 5.5 (6.7 with muscle biopsy) 'probable IIM', had the best sensitivity/specificity (87%/82% without biopsies, 93%/88% with biopsies) and is recommended as a minimum to classify a patient as having IIM.

Radiation Therapy Oncology Group consensus panel guidelines for the delineation of the clinical target volume in the postoperative treatment of pancreatic head cancer

The postoperative abdomen has been a difficult area for effective radiotherapy. These new guidelines will help physicians create fields that better encompass areas at risk and minimize dose to normal tissues.

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