Antibiotic Therapy of 3 Days May Be Sufficient After Biliary Drainage for Acute Cholangitis: A Systematic Review

Guideline recommendations vary between 4 and 14 days after biliary drainage. Short-course therapy of 3 days is sufficient in cholangitis patients with common bile duct stones, say researchers. Recurrent chol Changitis occurred in 0-26.8% of patients treated with short- Course therapy.

Methotrexate Is Not Superior to Placebo in Maintaining Steroid-Free Response or Remission in Ulcerative Colitis

Parenteral methotrexate was not superior to placebo in preventing relapses of UC in patients who achieved steroid-free response during induction therapy. At week 48, 30% of patients in the placebo group (12/40) and 27% of those in the methotrexate group were in steroid-free clinical remission without the need for additional therapies.

EUS-guided fiducial placement for GI malignancies: a systematic review and meta-analysis

Study: EUS allows the delivery of radiation with high precision to a target lesion while minimizing toxicity to surrounding tissues.

Validity of randomized clinical trials in gastroenterology from 1964-2000

Review of all 383 randomized clinical trials published in GASTROENTEROLOGY as original articles from 1964 to 2000. The reported methodological quality improved significantly in the mid-1990s. The present study shows a positive development.

Peroral endoscopic myotomy as salvation technique post-Heller: International experience

Heller myotomy (HM) has an excellent efficacy rate but a number of patients remain symptomatic post-procedure. We present an international, multicenter experience evaluating the efficacy and safety of post-HM peroral endoscopic myotomy. For patients with persistent symptoms after HM, POEM is a safe salvation technique with good short-term efficacy.

Prediction of poor outcome in patients with acute liver failure-systematic review of prediction models

Liver transplantation is the only life-saving therapy for acute liver failure (ALF) There are many studies on prognostic models for ALF but they show methodological and reporting limitations

The influence of industry sponsorship on the reporting of subgroup analyses within phase III randomised controlled trials in gastrointestinal oncology

A number of industries performed per trial was significantly larger for the industry. Claims of subgroup effect were made in 52% of trials and 50% in CA. Only 25% of interaction evident in only 25%.

High quantity and variable quality of guidelines for acute pancreatitis: a systematic review

Guideline quality did not improve over time. Guidelines endorsed by a professional body had higher scores than those without official endorsement. Guidelines with tables, a recommendations summary, evidence grading, and audit goals had significantly higher scores. Further research is required to determine whether guideline quality alters clinical outcomes.

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