Usefulness of endoscopic ultrasound-guided fine-needle biopsy for the diagnosis of autoimmune pancreatitis using a 22-gauge Franseen needle: a prospective multicenter study

Detailed histological evaluation is important in the diagnosis of autoimmune pancreatitis (AIP). Study: EUS-FNB with a 22-gauge Franseen needle demonstrated favorable detection rates which would be clinically beneficial for the histological diagnosis of AIP.

Expert assessment on volumetric laser endomicroscopy full scans in Barrett's esophagus patients with or without high grade dysplasia or early cancer

Volumetric laser endomicroscopy allows for near-microscopic imaging of the superficial esophageal wall. It may improve detection of early neoplasia in Barrett's esophagus (BE) However, interpretation of a 6-cm long, circumferential VLE "full scan" may be challenging for endoscopists

Safety of Non-anesthesia Provider-Administered Propofol (NAAP) Sedation in Advanced Gastrointestinal Endoscopic Procedures: Comparative Meta-Analysis of Pooled Results

Study compared the safety of non-anesthesia provider (NAAP)-administered propofol sedation for advanced endoscopic procedures with those of anesthesia provider (AAP) Data were analyzed for hypoxia rate, airway intervention rates, endoscopist, and patient satisfaction scores

Helmet continuous positive airway pressure versus high-flow nasal cannula in COVID-19: a pragmatic randomized clinical trial (COVID HELMET)

Oxygen delivery by helmet continuous positive airway pressure (CPAP) is a feasible option. It enables a higher positive positive end-expiratory pressure (PEEP). We plan to perform an investigator-initiated, pragmatic, randomized trial at an intermediate-level COVID-19 cohort ward in Helsingborg Hospital in Sweden. Helmet CPAP enables a higher positive positive end-expiratory pressure (PEEP) It could have important implications during the current COVID-19 epidemic.

Demographic risk factors for COVID-19 infection, severity, ICU admission and death: a meta-analysis of 59 studies

Age and sex are associated with the risk of COVID-19 in different severity stages ranging from infection to death. Patients aged 70 years and above have a higher infection risk and a higher need for intensive care. Men had a higher risk for infection than women.

Systematic review on current antiviral therapy in COVID-19 pandemic

There are several attempts to find an effective antiviral drug against the COVID-19. Up to 5-10% of patients may have severe, life-threatening events that urgently require effective drugs. None of the RCTs showed the efficacy of antiviral therapy. In the present pandemic and any future epidemics, all the related authorities should pursue many more RCTs, cohorts, and case series for a prospective outcome in the management and treatment guidelines.

Acute kidney injury and renal replacement therapy in COVID-19 patients: A systematic review and meta-analysis

A meta-analysis conducted to gain clarity regarding AKI incidence and renal replacement therapy (RRT) use in COVID-19 patients. We searched for COVID-19-related case reports published through 25 July 2020. The pooled incidence of AKI in 51 studies including 21,531 patients was RRT usage was reported in 39 studies of 17,664 patients.

Circulating Levels of Interleukin-6 and Interleukin-10, But Not Tumor Necrosis Factor-Alpha, as Potential Biomarkers of Severity and Mortality for COVID-19: Systematic Review with Meta-analysis

Cytokine storm is an uncontrolled overproduction of inflammatory cytokines. It is a major pathological feature of acute respiratory distress syndromes being severe manifestations of COVID-19. A literature search in electronic databases consisting of PubMed, Scopus, and Cochrane Library and in a hand searching of reference lists. IL-6 and IL-10 might have great potential as biomarkers for the disease severity and mortality in COVID-19 patients.

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