Randomized phase III study of bevacizumab plus FOLFIRI and bevacizumab plus mFOLFOX6 as first-line treatment for patients with metastatic colorectal cancer (WJOG4407G)

WJOG4407G was a randomized, open-label, phase III trial conducted in Japan. Patients with previously untreated mCRC were randomized 1:1 to receive FOLFIRI plus bevacizumab or mFOLFOX6.

Efficacy and Tolerability of High- vs Low-Volume Split-Dose Bowel Cleansing Regimens for Colonoscopy: A Systematic Review and Meta-analysis

It is not clear whether approved low-volume polyethylene glycol (PEG) regimens are as effective as high-volume PEG regimens when taken in a split dose. In an analysis of data from 17 randomized controlled trials, comprising 7528 patients, we found no significant differences inadequacy of.

Long-term efficacy and safety of biosimilar infliximab (CT-P13) after switching from originator infliximab: open-label extension of the NOR-SWITCH trial

NOR-SWITCH trial shows switching from infliximab originator to less expensive biosimilar CT-P13 was not inferior to continued treatment with infliximab.

Clinical and biological predictors of response to standardised paediatric colitis therapy (PROTECT): a multicentre inception cohort study

Pediatric patients aged 4-17 years with newly diagnosed ulcerative colitis were recruited from 29 centers in the USA and Canada. The primary outcome was week 52 corticosteroid-free remission with no therapy beyond mesalazine.

Quality of meta-analyses in major leading gastroenterology and hepatology journals: A systematic review

Country, a number of patients, funding sources were also revealed. Publication in recent years showed a significantly better methodological quality than those published in previous years.

Telemedicine and Mobile Health Technology Are Effective in the Management of Digestive Diseases: A Systematic Review

Mobile applications and interactive websites are an increasingly used method of telemedicine. This study aims to explore digestive disease studies that use telemedicine to effectively manage disease activity.

Gut Microbiota in Patients With Irritable Bowel Syndrome-A Systematic Review

Altering the gut microbiota has been proposed as a strategy for the treatment of IBS. Family Enterobacteriaceae (phylum Proteobacteria) and genus Bacteroides were increased in patients with IBS compared with controls.

The associations between fasting plasma glucose levels and mortality of COVID-19 in patients without diabetes

Pneumonia can rapidly progress to acute respiratory distress syndrome, septic shock, and multiple organ dysfunction syndromes. We aimed to clarify the associations between fasting plasma glucose levels and mortality of COVID-19 in patients without diabetes. Each tertile increment of FPG levels conferred 3.54-fold higher risks of death. Non-survivors combined with more comorbidities, more severe infection, and worse liver, kidney, and cardiac function in patients without diabetes.

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