Characteristics of pediatric multi-system inflammatory syndrome (PM(PMIS) associated with COVID-19: a meta-analysis and insights into pathogenesis

An outbreak of pediatric multisystem inflammation syndrome (PMIS) was observed in multiple countries recently. The syndrome was suspected to be associated with SARS-CoV-2 infection. 80% of patients suffered persistent fever and 90% appeared gastrointestinal symptoms. The study documented three common types of PMIS clinical presentation: persistent fever and gastrointestinal symptoms, shock with heart dysfunction, and Kawasaki disease-like syndrome.

Prevalence of Comorbid Asthma and Related Outcomes in COVID-19: A Systematic Review and Meta-Analysis

The impact of asthma on coronavirus disease 2019 (COVID-19) remains largely unknown. To investigate the asthma prevalence among patients with COVID-19 and compare outcomes between patients with and without asthma. Asthma is not associated with higher COVID-19 severity or worse prognosis. No significant difference in asthma prevalence was found between hospitalized and nonhospitalized patients. Patients with asthma are found to have a lower risk of death compared with patients without asthma.

The dysregulated innate immune response in severe COVID-19 pneumonia that could drive poorer outcome

The coronavirus disease 2019 (COVID-19) has peculiar characteristics and outcomes, suggesting a unique immunopathogenesis. 19 patients had lower levels of most classical inflammatory cytokines but higher plasma concentrations of CXCL10, GM-CSF, and CCL5. Immunocompetent non-COVID-19 and 27 COVID- 19 patients with severe pneumonia were prospective. Enrolled in a single-center, most requiring intensive care.

Clinical manifestations and outcomes of COVID-19 in the paediatric population: a systematic review

Coronavirus disease 2019 (COVID-19) has affected hundreds of thousands of people. We aim to report the distribution of cases, prevalence, and clinical, radiological, and laboratory signs and outcomes of COVID-19 in pediatric patients. Presentation of COVID-19 in children is mild and has a better prognosis. Children are likely to become a hidden source of infection because of their atypical presentation. No vaccine or specific antiviral is currently available.

Infection and mortality of healthcare workers worldwide from COVID-19: a systematic review

To estimate COVID-19 infections and deaths in healthcare workers (HCWs) from a global perspective during the early phases of the pandemic. Two parallel searches of academic bibliographic databases and grey literature were undertaken. A total of 152 888 infections and 1413 deaths were reported. Infections were mainly in women and nurses, but deaths mainly in men and doctors. Europe had the highest absolute numbers of reported infections (119 628) and deaths.

Targeting the NO-cGMP-PDE5 pathway in COVID-19 infection. The DEDALO project

A pandemic outbreak of COVID-19 has been sweeping the world since December. Some clinical trials are testing biological drugs to limit immune system dysregulation. The study reviewed all evidence documenting any involvement of the NO-cGMP-PDE5 axis. .Evidence suggests that PDE5 inhibitors could offer a new strategy in managing COVID-19. They could be counteracting the Ang-II-mediated downregulation of the AT-1 receptor.

[COVID-19 in orthopedics]

This is a systematic literature review for COVID-19, SARS-CoV-2 with Orthopedic and Spine Surgery relevance. It is to determine in Orthopedic Surgery and Spine Surgery The virus affects the ORF-8 protein of the Hemoglobin destroying B-Hemoglobin and IDC (intravascular disseminated coagulation) in many patients. Patients with hypertension tend to have a higher rate of suffering the disease. New care guidelines for COVID-19 patients are proposed based on the new research on SARS-CoV-2 clinical pat

Convalescent plasma may be a possible treatment for COVID-19: A systematic review Convalescent plasma may be a possible treatment for COVID-19: A systematic review

The coronavirus disease 2019 (COVID-19) pandemic has spread globally. Convalescent plasma immunotherapy was an effective method for fighting similar viral infections such as SARS-CoV. Limited safety data suggested that CP is a well-tolerated therapy with a low incidence of adverse events. Studies were common of low or very low quality. Some non-RCTs have found that CP may help patients improve clinical symptoms, clear the virus, and reduce mortality.

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