Multidonor intensive faecal microbiota transplantation for active ulcerative colitis: a randomised placebo-controlled trial

Fecal microbiota transplantation is a novel form of therapeutic microbial manipulation but its efficacy in ulcerative colitis is uncertain. Intensive-dosing, multi-donor.

Urgent endoscopic retrograde cholangiopancreatography with sphincterotomy versus conservative treatment in predicted severe acute gallstone pancreatitis (APEC): a multicentre randomised controlled trial

Randomised trial compared urgent endoscopic retrograde cholangiopancreatography with biliary sphincterotomy with conservative treatment in gallstone pancreatitis. The primary endpoint was mortality or major complications within 6 months of randomisation.

Efficacy and Safety of Early vs Elective Colonoscopy for Acute Lower Gastrointestinal Bleeding

170 patients with acute lower gastrointestinal bleeding were randomly assigned (1:1) to groups that underwent early colonoscopy. Rebleeding within 30 days of hospital admission occurred in 15.3% of patients in the early colonoscopic group and 6.7% in the elective group

AGA Institute Rapid Review of the Gastrointestinal and Liver Manifestations of COVID-19, Meta-Analysis of International Data, and Recommendations for the Consultative Management of Patients with COVID-19

Multiple gastrointestinal (GI) symptoms, including diarrhea, nausea/vomiting, and abdominal pain, have been reported in patients with coronavirus disease 2019 (COVID-19) This document provides best practice statements and recommendations for consultative management

A Placebo-Controlled Trial of Bezafibrate in Primary Biliary Cholangitis

Fibrates are agonists of peroxisome proliferator-activated receptors. They have shown potential benefit in patients with primary biliary cholangitis.

Prevalence, incidence, and outcome of non-alcoholic fatty liver disease in Asia, 1999-2019: a systematic review and meta-analysis

Non-alcoholic fatty liver disease is the most prevalent chronic liver disease worldwide. NAFLD prevalence in Asia is increasing and is associated with poor outcomes. Targeted public health strategies must be developed in Asia to target the drivers of this rising epidemic.

Histamine receptors and COVID-19

Reports that the histamine H2 receptor antagonist famotidine could help treat the novel coronavirus disease appeared from April 2020. A systematic literature search was performed by 19 September 2020. ClinicalTrials.gov was searched for COVID-19 and Famotidine may be a useful addition in COVID-19 treatment, In vitro studies have to date failed to show a direct inhibition of famotidine on SARS-CoV-2 replication. Results from prospective randomized trials are as yet awaited.

Safety and Efficacy of the BNT162b2 mRNA Covid-19 Vaccine

Severe acute respiratory syndrome coronavirus 2 has afflicted tens of millions of people in a worldwide pandemic. Safe and effective vaccines are needed urgently. The BNT162b2 vaccine candidate encodes a prefusion stabilized membrane-anchored SARS-CoV-2 full-length spike protein. The vaccine was 95% effective in preventing Covid-19 (95% credible interval, 90.3 to 97.6). Similar vaccine efficacy was observed across subgroups defined by age, sex, race, ethnicity, baseline body-mass index, and the

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