Asthma and COVID-19 in children: A systematic review and call for data

Asthma is the most common chronic disease in children. It is unclear whether asthma is a risk factor for coronavirus disease 2019. SARS-CoV-2 and COVID-19 have been linked to severe acute respiratory syndrome coronavirus 2 in pediatric populations. There is scarcely any data on whether childhood asthma constitutes risk factors for SARS-CoV-2 infection or COVID-19 severity. Studies are needed that go beyond counting the number of cases in the pediatric age range.

Effect of Bamlanivimab as Monotherapy or in Combination With Etesevimab on Viral Load in Patients With Mild to Moderate COVID-19: A Randomized Clinical Trial

Coronavirus disease 2019 (COVID-19) continues to spread rapidly worldwide. Neutralizing antibodies are a potential treatment for the disease. To determine the effect of bamlanivimab monotherapy and combination therapy with bamlanivimab and etesevimab on severe acute respiratory syndrome coronavirus 2. The BLAZE-1 study is a randomized phase 2/3 trial at 49 US centers. The primary endpoint was a change in SARS-CoV-2 log viral load on day 11. No significant difference in viral load reduction was o

COVID-19 and cutaneous manifestations: a systematic review

The cutaneous manifestations of COVID-19 patients have been increasingly reported, but not summarized, and the potential mechanisms remain to be investigated. The receptor of SARS-CoV-2, ACE2, was found to be expressed on skin, mainly on keratinocytes. Our review systematically presented the clinical characteristics of 507 patients and showed that skin might be the potential target of the infection according to ACE2 expression. Erythema, chilblain-like, and urticarial lesions were the most commo

Clinical manifestations of children with COVID-19: A systematic review

The coronavirus disease 2019 (COVID-19) outbreak is leading to thousands of deaths every day worldwide. Despite epidemiological importance, clinical patterns of children with COvid-19 remain unclear. Abnormalities in computed tomography were reported in 63.0% of cases. Clinical manifestations of children with COVID-19 differ widely from adult cases. Fever and respiratory symptoms should not be considered a hallmark of COVID-19 in children.

Does COVID-19 contribute to the development of neurological disease?

The coronavirus disease 2019 (COVID-19) has been associated primarily with pneumonia. Recent data show it can infect a large number of vital organs beyond the lungs, such as the heart, kidneys, and brain. The threat to the central nervous system is expected. Neurons and glial cells express ACE2 receptors in the CNS. This review correlates the present clinical manifestations of COVID-19 patients with possible neurological consequences in the future.

REGN-COV2, a Neutralizing Antibody Cocktail, in Outpatients with Covid-19

Complications and death from coronavirus disease 2019 (Covid-19) may be related to high viral loads. Two fully human, neutralizing monoclonal antibodies against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike protein were used. Key endpoints included the time-weighted average change in viral load from baseline (day 1) through day 7. Safety outcomes were similar in the combined REGN-COV2 dose groups and the placebo group.

Prevalence and impact of cardiovascular metabolic diseases on COVID-19 in China

Cardiovascular metabolic comorbidities made patients more susceptible to the 2019 novel coronavirus ( 2019-nCoV) disease. A meta-analysis of eligible studies summarizes the prevalence of cardiovascular metabolic diseases in COVID-19. At least 8.0% of patients with COVID-19 suffered an acute cardiac injury. Patients with previous cardiovascular metabolic diseases may face a greater risk of developing into the severe condition. On the other hand, COVID-19 can, in turn, aggravate the damage to the

Diagnostic accuracy of serological tests for covid-19: systematic review and meta-analysis

Covid-19 is a new strain of the coronavirus. From 1 January to 30 April 2020, using subject headings or subheadings combined with text words. Eligible studies measured sensitivity or specificity, or both of a covid- 19 serological test compared with a reference standard. Only two studies evaluated tests at the point of care. High-quality clinical studies assessing the diagnostic accuracy of serological tests for covid-19 are urgently needed.

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