Prevalence, incidence, and outcome of non-alcoholic fatty liver disease in Asia, 1999-2019: a systematic review and meta-analysis

Non-alcoholic fatty liver disease is the most prevalent chronic liver disease worldwide. NAFLD prevalence in Asia is increasing and is associated with poor outcomes. Targeted public health strategies must be developed in Asia to target the drivers of this rising epidemic.

Joint ESPGHAN/NASPGHAN Guidelines for the Management of Helicobacter pylori in Children and Adolescents (Update 2016)

Recommendations for diagnosing and managing H pylori infection in children and adolescents are required. Antibiotics should be tailored according to susceptibility testing to reach the aim of a 90% eradication rate with initial therapy.

Selecting Therapeutic Targets in Inflammatory Bowel Disease (STRIDE): Determining Therapeutic Goals for Treat-to-Target

STRIDE program examined potential treatment targets for inflammatory bowel disease. The group agreed upon 12 recommendations for ulcerative colitis (UC) and Crohn's disease (CD) The agreed target for UC was clinical/patient-reported outcome remission

Canadian Association of Gastroenterology Clinical Practice Guideline for the Medical Management of Pediatric Luminal Crohn's Disease

The group suggested exclusive enteral nutrition for induction therapy and biologic tumor necrosis factor. No consensus was reached on the role of aminosalicylates.

The characteristics of gastrointestinal symptoms in patients with severe COVID-19: a systematic review and meta-analysis

Although primarily a respiratory illness, several studies have shown that COVID-19 causes elevation of liver enzymes and various gastrointestinal (GI) symptoms. We conducted a systematic review and meta-analysis to determine whether the presence of gastrointestinal symptoms contributed toward severe CO VID-19 severity. We found that the severe COVIid-19 patients significantly had abdominal pain compared to the non-severe patients. No significant difference in the incidence of diarrhea, nausea, o

Lactobacillus stress protein GroEL prevents colonic inflammation

We previously showed that supernatants of Lactobacillus biofilms induced an anti-inflammatory response by affecting the secretion of macrophage-derived cytokines. In mice, rectal administration of L. reuteri GroEL (but not E. coli GroEL) inhibited all signs of hemorrhagic colitis including rectal bleeding and weight loss. GroEL, by affecting macrophage inflammatory features, deserves to be explored as an alternative to probiotics.

Pathways for the development of multiple epithelial types of intraductal papillary mucinous neoplasm of the pancreas

The intraductal papillary mucinous neoplasm of the pancreas is categorized into four distinct types. Each type is associated with specific clinicopathological features. We obtained 103 lesions of various types, including 49 gastric, 26 intestinal, 22 pancreaticobiliary. Comparative analysis was performed by targeted sequencing of 37 genes in different lesion types within each pancreas. Gastric-type low-grade lesions have a risk of progression into high-grade lesions of other types.

Respiratory Tract Manifestations of Inflammatory Bowel Disease

Inflammatory bowel disease can manifest in many extraintestinal organ systems. Most frequently involved extraintestinal locations include mucocutaneous, hepatobiliary, and ocular organ systems. The respiratory tract is less commonly involved and is therefore frequently overlooked. It is believed that the involvement of the respiratory tract in patients with inflammatory bowel disease is underreported. Some conditions related to respiratory tract involvement might be subclinical, but others may h

Departments

Recent Posts