Colorectal cancer in 18- to 49-year-olds: rising rates, presentation, and outcome in a large integrated health system

New guidelines recommend screening should begin at age 45. Younger patients are more likely to have metastases and to need multimodality treatment.

Safety and efficacy of water pressure endoscopic submucosal dissection for colorectal tumors with submucosal fibrosis (with video)

Water pressure endoscopic submucosal dissection can shorten procedure time for fibrotic colorectal neoplasms. Median procedure time was significantly shorter in the WP- ESD group than in the C-EsD group. Four of 11 patients with perforation using WP-ESd showed fluid collection on postprocedural MDCT images.

Diabetes Mellitus is Associated with Severe Infection and Mortality in Patients with COVID-19: A Systematic Review and Meta-analysis

The number of patients with coronavirus disease 2019 (COVID-19) infection is increasing rapidly worldwide. This study aimed to assess whether diabetes mellitus (DM) would increase the risk of severe infection and death in patients with the disease.

Prevalence, clinical characteristics, and outcomes of pediatric COVID-19: A systematic review and meta-analysis

The novel coronavirus pandemic is an ongoing challenge faced by the public and health care systems around the globe. The majority of information and evidence gathered so far regarding COVID-19 has been derived from data and studies in adult populations. All relevant studies until June 16, 2020, were included in the study.

A systematic review and meta-analysis: the effect of active cancer treatment on severity of COVID-19

Death rate may increase up to 25% in solid malignancies. Safety concerns regarding cancer treatment has increased over time. Primary end-points were severe disease and death in the cancer patients treated within the last 30 days before COVID-19 diagnosis.

Rehabilitation and COVID-19: the Cochrane Rehabilitation 2020 rapid living systematic review. Update as of August 31st, 2020

Thirty-two studies (62.7%) included COVID-19 patients who were assessed in the acute (20/32) or post-acute phases. The scientific literature of August 2020 mainly focused on limitations in the functioning of nervous system structure and related functions.

B Cell Subsets as Severity-Associated Signatures in COVID-19 Patients

frequency of CD19+ B cells is increased in severe COVID-19 compared to mild cases. Specific subset frequencies such as transitional B cell subsets increase in mild/moderate cases but decrease with the severity of the disease.

Prevalence and predictors of death and severe disease in patients hospitalized due to COVID-19: A comprehensive systematic review and meta-analysis of 77 studies and 38,000 patients

Death prevalence from COVID-19 was 20% (18-23%) in the US and Europe and 11% (7-16%) for China. The prevalence of hypertension (55%), diabetes (33%), smoking history (23%) and heart disease (17%) among the hospitalized patients in the U.S. were substantially higher than that of the general US population.

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