TAK-101 Nanoparticles Induce Gluten-Specific Tolerance in Celiac Disease: A Randomized, Double-Blind, Placebo-Controlled Study

Gliadin protein (gliadin) encapsulated in negatively charged poly(dl-lactide-co-glycolic acid) nanoparticles is designed to induce gluten-specific tolerance.

Ethnicity associations with food sensitization are mediated by gut microbiota development in the first year of life

In this study, we characterized the composition of fecal microbiota in 1422 Canadian full-term infants. Atopic sensitization outcomes were measured by skin prick tests at age 1 year and 3 years. Four developmental trajectories of gut microbiota were shaped by birth mode and varying by ethnicity.

Fully Covered Self-Expanding Metal Stent versus Multiple Plastic Stents to Treat Benign Biliary Strictures Secondary to Chronic Pancreatitis: A Multicenter Randomized Trial

Benign biliary strictures are complications of chronic pancreatitis. The study compared 12-month treatment with MPS and FCS EMS. At 24 months, MPS treatment was more effective and had fewer ERCPs than FCS EMS. No stent- or procedure-related deaths occurred.

Gluten Degradation, Pharmacokinetics, Safety, and Tolerability of TAK-062, an Engineered Enzyme to Treat Celiac Disease

Celiac disease (CeD) is an immune-mediated disorder triggered by the ingestion of gluten. TAK-062 is a novel, computationally designed endopeptidase under development for the treatment of patients with CeD.

Gastric cancer still represents a major cancer burden worldwide. Persistent decreasing trends in gastric cancer incidence rates were observed from 1988 to 2012 worldwide

Gastric cancer still represents a major cancer burden worldwide. Persistent decreasing trends in gastric cancer incidence rates were observed from 1988 to 2012 worldwide

Paternal Exposure to Immunosuppressive and/or Biologic Agents and Birth Outcomes in Patients with Immune-Mediated Inflammatory Diseases

In a large cohort study of 7,453 expectant fathers with IMIDs, exposure to immunosuppressive or biologic agents around conception was not associated with an increased risk of adverse birth outcomes

Chinese herbal medicine for COVID-19: Current evidence with systematic review and meta-analysis

There is currently no drug or therapy that cures COVIid-19, a highly contagious and life-threatening disease. Compared to standard care, CHM plus SC had a superior effect on the change of symptom and sign score.

Computational drug discovery and repurposing for the treatment of COVID-19: A systematic review

Computational methods of drug repurposing offer the best chance of selecting one drug from a list of approved drugs. Studies included repurposed drugs mainly against non-structural proteins of SARS-Co

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