Deleterious variants in ABCC12 are detected in idiopathic chronic cholestasis and cause intrahepatic bile duct loss in model organisms

CRISPR/Cas9 genome editing was employed to induce pathogenic variants in the candidate gene. MRP9-deficient mice had fewer well-formed interlobular bile ducts and higher serum alkaline phosphatase levels compared to WT mice.

Familial burden and other clinical factors associated with various types of cancer in individuals with Lynch syndrome

LS is associated with increased risks of various gastrointestinal, gynecologic, genitourinary, and other cancers. Many clinical practice guidelines recommend that LS carriers' screening strategies be devised based on their family history of various cancers.

Outcomes of thermal ablation of the mucosal defect margin after endoscopic mucosal resection: A prospective, international, multi-centre trial of 1000 large non-pedunculated colorectal polyps

Thermal ablation of the defect margin after endoscopic mucosal resection has shown efficacy in a randomized trial with a four-fold reduction in residual adenoma

A Liquid Biopsy Assay for Noninvasive Identification of Lymph Node Metastases in T1 Colorectal Cancer

Study: Translates tissue-based biomarkers into a blood-based liquid biopsy for noninvasive detection of lymph node metastasis. The Risk-stratification model is more accurate than the panel and an independent predictor for the identification of LNM.

Epithelia-sensory neuron crosstalk underlies cholestatic itch induced by lysophosphatidylcholine

Previous studies implicated lysophosphatidic acid (LPA) as a potential mediator of cholestatic pruritus. Pruritogenicity of LPC, LPA's precursor, was examined in mice and nonhuman primates.

BCL3 couples cancer stem cell enrichment with pancreatic cancer molecular subtypes

Pancreatic ductal adenocarcinoma (PDAC) has different subtypes and their correlation with patient outcomes. B-cell CLL/lymphoma 3 (BCL3) was significantly downregulated in human CSCs. Overexpression of BCL3 in human PDXs diminished tumor growth by significantly reducing the CSC population and promoting differentiation.

BMP pathway antagonism by Grem1 regulates epithelial cell fate in intestinal regeneration

Intestinal regeneration is underpinned by dedifferentiation and cell plasticity. We spatiotemporally mapped BMP signaling in mouse and human regenerating intestine

Airborne transmission of COVID-19 and the role of face mask to prevent it: a systematic review and meta-analysis

SARS-CoV-2 is an agent of 2019 novel coronavirus disease (COVID-19) It emerged in Wuhan, Hubei province of China, in early December 2019 and is now considered a pandemic.

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