Effect of denosumab on osteolytic lesion activity after total hip arthroplasty: a single-centre, randomised, double-blind, placebo-controlled, proof of concept trial

Osteolysis causes recurrent pain and disability after total hip arthroplasty. We investigated the effect of the human monoclonal antibody denosumab on osteolytic lesion activity. No deaths or treatment-related serious adverse events occurred. This is the first clinical trial of an investigational drug for osteolytic that shows tissue-specific biological efficacy.

Hedgehog concept in Healthcare practice

Hedgehogs are good at one thing and survive in spite of multiple attacks by their predators. They do it by one strategy which they do it good all the time rather than focusing on multiple half hearted strategies. It's important to understand the hedgehog concept and apply in our life and healthcare practice to be successful.

Covaxin may face hurdles post Brazil’s move to halt its import

Bharat Biotech International's Covaxin was refused an emergency use licence in Brazil due to suspected serious lapses at its Hyderabad plant. Other health authorities, as well as the World Health Organization, may be slow to approve the Indian-made covid vaccine, according to experts. Others hypothesised that BharatBiotech could still be able to fulfil the Brazilians' needs.

Prevalence of Keratoconus Based on Scheimpflug Imaging

The Raine Study is a multigenerational, longitudinal cohort study based in Perth, Western Australia. Of the 1259 participants, 50.8% were women and 85.7% were White. 15 participants had keratoconus in at least 1 eye, giving a prevalence of 1 in 84.

Association Between Benzodiazepine or Z-Drug Prescriptions and Drug-Related Poisonings Among Patients Receiving Buprenorphine Maintenance: A Case-Crossover Analysis

Benzodiazepine and Z-drug use is linked with drug-related poisonings among patients receiving buprenorphine maintenance treatment. Buprenorphine's associated with a nearly 40% reduction in the risk of poisoning events.

68Ga-FAPI-04 PET-CT for molecular assessment of fibroblast activation and risk evaluation in systemic sclerosis-associated interstitial lung disease: a single-centre, pilot study

Lung disease is the most common cause of death in systemic sclerosis. It is judged by the accrual of lung damage on CT and pulmonary function tests. The antifibrotic drug nintedanib might improve risk assessment. The study is the first-in-human evidence that fibroblast activation correlates with disease progression in the lungs of patients with MS.

Artificial Intelligence System to Determine Risk of T1 Colorectal Cancer Metastasis to Lymph Node

Most patients with T1 colorectal cancers undergo surgical resection with lymph node dissection. There is a low incidence of metastasis to lymph nodes. We developed a machine-learning artificial neural network to identify patients with lymph nodes with metastases. This model might be used to determine which patients require additional surgery after endoscopic resection.

Recent Randomized Trials of Antithrombotic Therapy for Patients With COVID-19: JACC State-of-the-Art Review

Endothelial injury and microvascular/macrovascular thrombosis are common pathophysiological features of coronavirus disease-2019 (COVID-19). We searched ClinicalTrials.gov and the World Health Organization (WHO) International Clinical Trials Registry Platform. A variety of antithrombotic agents, doses, and duration of therapy are being assessed in ongoing randomized controlled trials. Table 1 summarizes study-level inclusion and exclusion.

Departments

Recent Posts