Use of hydroxychloroquine and risk of major adverse cardiovascular events in patients with lupus erythematosus: A Danish nationwide cohort study

Hydroxychloroquine may affect risk of cardiovascular disease in patients with lupus erythematosus (LE) An inverse association between use of hydroxychlorquine and cardiovascular events was observed.

Impact of the KCNQ2/3 Channel Opener Ezogabine on Reward Circuit Activity and Clinical Symptoms in Depression: Results From a Randomized Controlled Trial

This is the first randomized placebo-controlled trial to test the effect of the KCQ2-2 positive modulator ezogabine on reward circuit activity and outcomes in patients with depression. The study did not meet its primary neuroimaging endpoint

Preconception genome medicine: current state and future perspectives to improve infertility diagnosis and reproductive and health outcomes based on individual genomic data

Our genetic code is now readable, writable, and hackable. Extension of reproductive genetic risk assessment to the general population and IVF couples will lead to the identification of couples who carry recessive mutations. Clear genotype-phenotype associations are found for aberrant sperm types, oocyte maturation, fertilization, or pre-and post-implantation embryonic development.

Pista House Haleem and learnings for Healthcare professionals

How Pista House Haleem has evolved as a multi crore business in the month of Ramadan has many learnings for all of us. It has not only just been marked as a food delicacy but also as one of most compelling case studies to inspire in different industries. A few learnings which will be useful for healthcare professions are discussed here.

Seroprevalence of Immunoglobulin M and G Antibodies against SARS-CoV-2 Virus: A Systematic Review and Meta-Analysis Study

Coronavirus disease 2019 (COVID-19) is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) ) The average rate of positive cases for IgM (AU/mL) was 2.10 (95% CI: 1.65-2.55; I2=92.2%), and the sensitivity in individuals with positive IgM test was 63% (95%.

Association Between Renin-Angiotensin-Aldosterone System Inhibitors and Clinical Outcomes in Patients With COVID-19

The aim was to conduct a systematic review and meta-analysis comparing mortality and severe adverse events among patients receiving ACEIs or ARBs. Results showed significant reductions in the risk of death and severe AEs. Findings support the recommendations of medical societies, they say, but future trials are needed to confirm causality.

Mild versus conventional ovarian stimulation for IVF in poor, normal and hyper-responders: a systematic review and meta-analysis

Mild ovarian stimulation has emerged as an alternative to conventional IVF. It has the advantages of being more patient-friendly and less expensive. RCTs on IVF where comparisons were made between a mild. 150 IU daily dose and conventional stimulation in terms of clinical outcomes and cost-effectiveness. Compared to CD-VIVF, MD-IVF was associated with less gonadotrophin use and lower cost.

IVF and other ART in low- and middle-income countries: a systematic landscape analysis

Infertility affects 48.5 million couples worldwide with a prevalence estimated at 3.5–16.7% in low- and middle-income countries. ART services are not accessible to the majority of these infertile couples due to the high cost of treatments. This work will unfold the landscape of available and potential ART services in LMIC.

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