Relationship of the cycle threshold values of SARS-CoV-2 polymerase chain reaction and total severity score of computerized tomography in patients with COVID 19

Viral load was not a critical factor for hospitalization and mortality in SARS-CoV-2 RNA-positive patients. CT severity was related to age, and older patients had higher TSS. Outpatients had considerable amounts of virus in their nasopharynx, which made them contagious

Repurposing novel therapeutic candidate drugs for coronavirus disease-19 based on protein-protein interaction network analysis

The coronavirus disease-19 (COVID-19) emerged in Wuhan, China and rapidly spread worldwide. Currently, there are no effective drugs targeting SARS-CoV-2. Seven potential drugs were proposed for treatment using protein-protein interaction (PPI) network analysis.

Transfusion support in COVID-19 patients: Impact on hospital blood component supply during the outbreak

The study was to assess the effect of the COVID-19 outbreak on hospital blood supply. Most hospitals were expecting a decrease in the number of patients, but the true extent of the problem is uncertain

Identification of Endpoints for Development of Antifibrosis Drugs for Treatment of Crohn's Disease

The International Organization for the Study of Inflammatory Bowel Disease (IOIBD) aimed to identify a set of endpoints that can be used to determine the efficacy of anti-fibrosis drugs.

Safety and efficacy of antigen-specific regulatory T-cell therapy for patients with refractory Crohn's disease

Ovalbumin-specific Treg cells (ova-Tregs) were isolated from the patient's peripheral blood mononuclear cells ( PBMCs), exposed to ovalbumin, and administrated intravenously.

Polymorphisms of 5-HTT LPR and GNβ3 825C>T and Response to Antidepressant Treatment in Functional Dyspepsia: A Study from The Functional Dyspepsia Treatment Trial

Genotype of the 5-HTT LPR variant of the serotonin transporter gene (SLC6A4) has been linked to selective serotonin reuptake inhibitor (SSRI) response

High-Fiber Orange Juice as a Nutrition Supplement in Women: A Randomized, Double-Blind, Placebo-Controlled Study of Tolerance and Effectiveness

Orange juice was found to be efficient to achieve the daily fiber intake recommendation for women. The fiber-enriched orange juice was not accompanied by intense adverse events.

No benefit of endoscopic sphincterotomy before biliary placement of self-expandable metal stents for unresectable pancreatic cancer

ES is placed in malignant pancreatic cancer patients to prevent postprocedural esophageal cancer. It is not clear whether ES actually prevents pancreatitis or affects other adverse events. We conducted a noninferiority trial to see if the placement had any effect on cancer survival.

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