Is routine sedation or topical pharyngeal anesthesia beneficial during upper endoscopy?

The benefits of routinely administered sedative medication or topical pharyngeal anesthesia are controversial. The aim of this study was to clarify their effects on patient tolerance and the difficulty of upper endoscopy.

Randomised clinical study: comparison of acceptability, patient tolerance, cardiac stress and endoscopic views in transnasal and transoral endoscopy under local anaesthetic

Transnasal endoscopy (TNE) with ultrathin endoscopes has been advocated as an attractive alternative to SOGD. The aim was to assess tolerability, acceptability, and quality of TNE, in comparison with a standard upper endoscope.

A randomised clinical trial of transnasal endoscopy versus fluoroscopy for the placement of nasojejunal feeding tubes in patients with severe acute pancreatitis

100 patients with severe acute pancreatitis were randomized to receive NJTs by transnasal endoscopy or fluoroscopy. The successful placement was confirmed by an abdominal radiograph.

The safety and sensitivity of a telemetric capsule to monitor gastrointestinal hydrogen production in vivo in healthy subjects: a pilot trial comparison to concurrent breath analysis

Intestinal gases are currently used for the diagnosis of disorders including small intestinal bacterial overgrowth and carbohydrate malabsorption. The capsule measured >3000 times higher concentrations of hydrogen compared to breathe tests, resulting in a signal-to-noise ratio of 23.4 for the capsule compared to 4.2 for the breath test.

Recombinant vaccines for COVID-19

SARS-CoV-2, the causative agent of COVID-19, has imposed a major public health threat. Several potential candidate vaccines being rapidly developed are in clinical evaluation. Safety is a major aspect to be considered before deploying such vaccines to the public.

The demand for a COVID-19 vaccine in Ecuador

Ecuador was one of the first and most severely affected by the COVID-19 pandemic. Survey results show that a very large proportion of individuals were willing to accept a vaccine, and at least 85% of individuals would pay a positive amount. Regression results show that WTP for the vaccine was associated with income, employment status, the perceived probability of needing hospitalization if contracting the virus causing COVID-19, and region of residence.

Parents' and guardians' views on the acceptability of a future COVID-19 vaccine: A multi-methods study in England

The availability of a COVID-19 vaccine has been heralded as the key to controlling the -19 pandemic. Success will rely on public willingness to be vaccinated, according to a new study. The study looked at how COVID-19 vaccines are developed and tested, including their safety and efficacy. It identified factors that may affect vaccine acceptability in ethnic minority and lower-income groups who are disproportionately affected by the vaccine.

Evaluation of COVID-19 Vaccine Refusal in Parents

The aim of the study was to predict the frequency of vaccine refusal against domestic and foreign COVID-19 vaccines. The most common reasons for refusal were anxiety about vaccine side effects, lack of knowledge about the effectiveness of vaccines, and distrust of vaccines originating from abroad. This study demonstrates that vaccine uptake can be increased by considering the higher preference for domestic vaccines.