Outcomes of radiofrequency ablation by manual versus self-sizing circumferential balloon catheters for the treatment of dysplastic Barrett’s esophagus: a multicenter comparative cohort study

Radiofrequency ablation is the preferred ablative modality for treating dysplastic Barrett's esophagus. A self-sizing circumferential ablation catheter eliminates the need for a sizing balloon. Procedure time was significantly shorter in the self-Sizing group. The primary outcome was the rate of adverse events, including strictures, perforation, and bleeding. A self-sizing system may enhance the efficiency of RFA for treating dysplastic Barrett's esophagus.

Prospective development and validation of a volumetric laser endomicroscopy computer algorithm for detection of Barrett’s neoplasia

Volumetric laser endomicroscopy is used to detect Barrett's esophagus (BE) dysplasia. Real-time interpretation of VLE scans is complex and time-consuming. VLE PREDICT study prospectively enrolled 47 patients with Barrett's esophagus (BE) dysplasia. In total, 229 non-dysplastic BE and 89 neoplastic targets were laser marked. Deep convolutional neural networks were used to construct a CAD algorithm. The algorithm detected neoplasia with high accuracy and outperformed 10 VLE experts.

Blown-out myotomy: an adverse event of laparoscopic Heller myotomy and peroral endoscopic myotomy for achalasia

Although laparoscopic Heller myotomy (LHM) or peroral endoscopic myotomy (POEM) is highly effective,10% to 20% of patients with achalasia remain symptomatic after treatment. We observed a pattern of failure associated with a pseudodiverticulum, or blown-out myotomy (BOM) LHM was more common than POEM and had a greater post-treatment integrated relaxation pressure.

Safety and feasibility of same-day discharge after esophageal endoscopic submucosal dissection

Endoscopic submucosal dissection is used for treating early luminal GI cancers. SDD is the standard of care in Asia, where it results in multiday admissions for observation. Of 96 patients undergoing a total of 140 ESDs, 85 were SDD versus 55 admissions. An experienced endoscopist can determine if SDD can be considered.

Safety and effectiveness of peroral endoscopic myotomy in patients on antiplatelet or anticoagulant therapy: an international multicenter case-control study

The risk of bleeding and thromboembolic events in patients undergoing peroral endoscopic myotomy (POEM) who are receiving antithrombotic therapy is unknown. Our primary aim was to assess the safety of POEM in this patient subset. Secondary outcomes were rates of clinical success, GERD, and procedure-related outcomes.POEM is safe and effective in patients receiving antithrombotic therapy although it is associated with a greater risk of major bleeding.

Automated software-assisted diagnosis of esophageal squamous cell neoplasia using high-resolution microendoscopy

High-resolution microendoscopy provides subcellular imaging of esophageal mucosa but requires expert interpretation. We compared endoscopists with an automated software algorithm for the detection of esophageal squamous cell neoplasia (ESCN) Software algorithm interpreted all images as neoplastic or non-neoplastic. The automated interpretation would facilitate widespread usage in resource-poor areas.

FACTORS ASSOCIATED WITH CORPOROGLANDULAR SHUNTING FOR PATIENTS WITH FIRST-TIME ISCHEMIC PRIAPISM

The study looked at patients who failed intracavernosal injection therapy and required shunting during first-time ischemic priapism episodes. Optimal cut-off values for each were found to be 950 mcg and 15.5 hours. The study suggests patients who require more than 950.

Clinical relevance of endoscopic treatment for superficial pharyngeal cancer: feasibility of techniques corresponding to each location and long-term outcomes

Superficial pharyngeal cancers are being detected and treated using endoscopy with increasing frequency. We identify reliable treatments by adapting the method for each region of the pharynx. Procedure time was 51 minutes at location A where cancer develops most commonly. The 5-year survival rate was 84.1% and cause-specific survival was 100%. Endoscopic Treatment of superficial pharyngeal cancer is both feasible and beneficial.

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