Long-term safety and efficacy of patisiran for hereditary transthyretin-mediated amyloidosis with polyneuropathy: 12-month results of an open-label extension study

Hereditary transthyretin-mediated amyloidosis is a rare, inherited, progressive disease caused by mutations in the tranStHyretin (TTR) gene. The global OLE is ongoing with no new enrolment, and current findings are based on the interim analysis of the patients who had completed 12-month efficacy assessments as of the data cutoff. Continued long-term follow-up will be important for the overall assessment of safety and efficacy with patisirans

Effect of length of surgery on the incidence of venous thromboembolism after benign hysterectomy

Venous thromboembolism is a leading cause of morbidity and mortality postoperatively. The study aimed to determine the effect of length of surgery, or operative time, on the risk of venous thrombi. For each 60-minute increase in operative time, there was a 35% increase in the odds of the disease. Minimally invasive hysterectomy had lower odds of venous thrombi Embolism than abdominal hysterectomy across all time points.

Molecular Mechanism of Action of Repurposed Drugs and Traditional Chinese Medicine Used for the Treatment of Patients Infected With COVID-19: A Systematic Scoping Review

This systematic scoping review provides an overview of the molecular mechanism of action of repurposed drugs. Traditional Chinese Medicine plays a pivotal role in triggering the inflammation pathway, such as the neuraminidase blocker, to fight the virus.

A practical approach for vaccinations including COVID-19 in autoimmune/autoinflammatory rheumatic diseases: a non-systematic review

The COVID-19 pandemic has occupied the world agenda since December 2019. Low-degree immunosuppression does not appear to decrease antibody responses to vaccines.

Protection From COVID-19

Since the beginning of 2020, the SARS-CoV-2 virus has spread to nearly every country. It is not yet clear whether and when population-wide immunity will be achieved. As many as 20 000 droplets ranging in size from 20 to 500 molecules are released every second.

Recent Advances on Nanomaterials to COVID-19 Management: A Systematic Review on Antiviral/Virucidal Agents and Mechanisms of SARS-CoV-2 Inhibition/Inactivation

Nanomaterials can be effectively used to detect, capture/inactivate, or inhibit coronavirus cell entry/replication. Nano carbons, biopolymeric, copper, and silver nanoparticles are potential antiviral and virucidal agents. Trends in toxicology research and safety tests can help fill the main gaps in the literature.

Nutritional status, hyperkalaemia and attainment of energy/protein intake targets in haemodialysis patients following plant-based diets: a longitudinal cohort study

Patients undergoing hemodialysis are often discouraged from eating fruits and vegetables because of fears of hyperkalemia and undernutrition. We performed an observational single-center study of stable patients undergoing HD with repeated dietary assessment every 3 months. A plant-based diet was not associated with serum potassium, hyperkalemia, or differences in energy intake. Patients with a high HPDS did not differ in terms of energy intake but were at risk of low protein intake.

Changes in Family Poverty Status and Child Health

Poverty and child weight status, asthma, and health-related quality of life (HRQoL). Study analyzed data for 3968 children from the Generation R Study, a population-based cohort study in the Netherlands. Transition out of poverty before age 2 was associated with a lower risk of asthma and a higher physical HRQoL. Support for children and families with a low household income is warranted.

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