Urinary chloride concentration and progression of chronic kidney disease: results from the KoreaN cohort study for Outcomes in patients With Chronic Kidney Disease

Urinary chloride is regulated by kidney transport channels. High urinary chloride concentration in the distal tubules can trigger tubuloglomerular feedback. Little attention has been paid to urinary chloride as a biomarker of clinical outcomes. We studied the relationship between urinary chloride concentration and chronic kidney disease. For every 25 mEq/L increase in urinary chloride, there was an 11% lower risk for CKD progression. Low urinary chloride concentration was associated with a highe

Mortality and adverse events of special interest with intravenous belimumab for adults with active, autoantibody-positive systemic lupus erythematosus (BASE): a multicentre, double-blind, randomised, placebo-controlled, phase 4 trial

Belimumab is approved for the treatment of active systemic lupus erythematosus. BASE was a double-blind, randomised, placebo-controlled, phase 4 trial done in 33 countries. Ten patients in the belimumab group died versus eight in the placebo group.

Evidence-based benchmarks for use of cancer surgery in high-income countries: a population-based analysis

Surgical treatment was indicated in 58% of newly diagnosed patients with cancer in Australia in 2014 at least once during the course of their treatment. The model provides a new template for high-income and emerging economies to rationally plan and assess their cancer surgery provision.

Pediatric Emergency Department Visits at US Children’s Hospitals During the COVID-19 Pandemic

The impact of the coronavirus disease 2019 (COVID-19) pandemic on pediatric emergency department (ED) visits is not well characterized. We aimed to describe the epidemiology of pediatric ED visits and resource use during the pandemic. ED visit rates decreased by 45.7% (average 911 026 ED visits over 2017– 2019 vs 495 052 visits in 2020) The largest decrease occurred among visits for respiratory disorders. The pandemic was associated with a relative increase in the proportion of visits for childr

Impact of Urology Trainee Debt Levels on Future Practice Choices and Expectations

Study: Workforce policy should consider addressing the financial burden of urology trainees. Trainees with a higher level of debt were more likely to anticipate higher annual compensation

Causal Associations of Anthropometric Measurements with Fracture Risk and Bone Mineral Density: A Mendelian Randomization Study

Each increase in height equal to a single standard deviation (SD) was associated with a 9.9% increase in the risk of fracture. BMI was causally associated with eBMD, but not with fracture.

A Multicenter Pilot Randomized Clinical Trial of a Home-Based Exercise Program for Patients With Cirrhosis: The Strength Training Intervention (STRIVE)

We developed the strength training intervention(STRIVE) is a home-based exercise program targeting physical function in patients with cirrhosis. Only 14% of participants adhered to the strength training video for 10–12 weeks. STRIVE was safely administered at 3 sites, but adherence was low. All participants showed minimal improvement in the LFI.

Comparative Effectiveness of Famotidine in Hospitalized COVID-19 Patients

Famotidine has been posited as a potential treatment for coronavirus disease 2019. The study population was COVID-19 hospitalized patients aged 18 years or older. Patients dispensed medication containing 1 of the 3 drugs on the day of admission. Similar results were observed for the risk of death or intensive services user.

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