Genetic and clinical characteristics of treatment-resistant depression using primary care records in two UK cohorts

Treatment-resistant depression is a major contributor to the disability caused by a major depressive disorder (MDD) Primary care electronic health records provide an easily accessible approach to investigate TRD clinical and genetic characteristics.

Forecasting seizure risk in adults with focal epilepsy: a development and validation study

Evidence from studies using chronic EEG (cEEG) revealed that epileptic brain activity shows robust cycles. Forecasts with a shorter horizon of 1 h, possible only for electrographic seizures in the development cohort, showed IoC in all 18 (100%) patients. This study shows that seizure probability can be forecasted days in advance by leveraging multidien IEA cycles recorded with an implanted device.

The influence of timing of surgical decompression for acute spinal cord injury: a pooled analysis of individual patient data

There is a strong biological rationale for early decompression of the injured spinal cord, but the influence of the timing of surgical decompression for acute spinal cord injury (SCI) remains debated. We aimed to objectively evaluate the effect of timing of decompressive surgery on long-term neurological outcomes. Outcome data at 1 year after injury were available for 1031 patients. The first 24–36 h after injury appears to represent a crucial time window to achieve optimal neurological recovery

Prevalence and correlates of physical activity across kidney disease stages: an observational multicentre study

Physical inactivity is a major modifiable risk factor for morbidity and mortality. The study investigated the prevalence of physical inactivity and determined individual correlates of this behavior. Being older, female, and having a greater number of comorbidities were associated with greater odds of being physically inactive. Identifying stage-specific correlates of physical activity may help to prioritize factors in target groups of kidney patients and improve the development and improvement o

Enteropeptidase inhibitor SCO-792 effectively prevents kidney function decline and fibrosis in a rat model of chronic kidney disease

Inhibiting enteropeptidase suppresses food intake and ameliorates obesity and diabetes in mice. The study found a decline in glomerular filtration rate (GFR) for five weeks with SCO-792. It also improved glomerulosclerosis and kidney fibrosis. It did not affect the renal plasma flow, suggesting its effect on GFR was mediated by an improved filtration fraction.SCO-792-mediated inhibition of enteropeptidase prevented GFR decline, albuminuria, and kidney fibrosis; hence, it may have therapeutic pot

The receptor activator of nuclear factor κΒ ligand receptor leucine-rich repeat-containing G-protein-coupled receptor 4 contributes to parathyroid hormone-induced vascular calcification

In chronic kidney disease, serum phosphorus (P) elevations stimulate parathyroid hormone (PTH) production. PTH is the main regulator of the receptor activator of the nuclear factor B (RANK/RANK ligand) system. It is essential for bone maintenance and plays an important role in vascular smooth muscle cell calcification.

Cardiopulmonary resuscitation (CPR) training strategies in the times of COVID-19: a systematic literature review comparing different training methodologies

Study compared learning outcomes of standard in-person CPR training with alternative methods of training. Trainees in the hybrid group performed better on calling 911.

The efficacy and safety of hydroxychloroquine (HCQ) in treatment of COVID19 -a systematic review and meta-analysis

Hydroxychloroquine (HCQ) has been one of the most widely tested drugs for SARS CoV2 on account of its antiviral properties. This systematic review and meta-analysis addresses the efficacy and safety of HCQ.

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