The prioritisation of paediatrics and palliative care in cancer control plans in Africa

Cancer control plans in Africa were investigated. Ten plans discussed cancer control in the context of non-communicable diseases. Pediatric cancer was mentioned in 7 national plans, representing 5127 children, or 13% of the estimated continental burden for children aged 0-14 years. Palliative care was itemized in four budgets.

Poor maternal-neonatal outcomes in pregnant patients with confirmed SARS-Cov-2 infection: analysis of 145 cases

Millions of people have been affected globally by SARS-CoV-2. The percentage of patients who delivered vaginally was higher than those who experienced a cesarean section. Maternal and neonatal death rates were found to be 5% and 6%, respectively.

Rapid and visual detection of 2019 novel coronavirus (SARS-CoV-2) by a reverse transcription loop-mediated isothermal amplification assay

Methods: We designed primers specific to the orf1ab and S genes of SARS-CoV-2. Total viral RNA was extracted using the QIAamp Viral RNA Mini Kit. Assay: 58 specimens were confirmed to be positive and 72 were negative by RT-LAMP. sensitivity was 100% (95% CI 92.3%-100%), specificity 100% and sensitivity (95%)

SARS-CoV-2 RNA in plasma samples of COVID-19 affected individuals: a cross-sectional proof-of-concept study

Plasma SARS-CoV-2 RNA seems to be associated with a worse COVID-19 outcome. Viremic patients were more frequently affected by hematological malignancies and had a higher viral load in respiratory samples

The utility of chest computed tomography (CT) and RT-PCR screening of asymptomatic patients for SARS-CoV-2 prior to semiurgent or urgent hospital procedures

In total, 625 patients were screened for SARS-CoV-2 using a combination of phone questionnaires, RT-PCR and chest computed tomography. Of the 625 patients, 520 scans (83.2%) were interpreted as normal. 18 scans (2.88%) had indeterminate features of COVID-19; and 86 (13.76%) had atypical features of the SARS virus. After surgery, none of the patients developed signs or symptoms suspicious of SARS that would indicate the need for surgery.

Evaluation of the RealStar® SARS-CoV-2 RT-PCR kit RUO performances and limit of detection

Assessment of the RealStar® SARS-CoV-2 RT-PCR Kit Research Use Only (Altona) compared with the WHO-PCr. Assay showed a slightly higher sensitivity with a limit of detection at 625 copies/mL instead of 1250 copies/L for the WHO. The overall percent agreement between RealStar and WHO- PCR on 83 clinical samples was 97.6% (81/83) with sensitivity at 97.8%.

SARS-CoV-2 seroprevalence worldwide: a systematic review and meta-analysis

SARS-CoV-2 has been arguably the most important public health concern worldwide in 2020. We used a random-effects model to estimate pooled seroprevalence and then extrapolated the findings to the global population (for 2020) This study showed that SARS- virus-2 seroprevalence varied markedly among geographic regions, as might be expected early in a pandemic.

Anti-SARS-CoV-2 IgG antibody response among Indian COVID-19 patients using β-propiolactone-inactivated, whole virus-based indirect ELISA

IgG response was studied in relation to duration and severity of illness. The igG detection rate was higher in patients with severe disease. The BPL inactivated virus-based ELISA could detect IgG antibodies early and in a significant proportion of patients suggesting its potential utility as a supplement to the currently used viral RNA detection tests.

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