Chronic low-dose intravenous immunoglobulins as steroid-sparing therapy in myasthenia gravis

Intravenous immunoglobulin (IVIg) has been proven beneficial in myasthenic crisis, but their role as maintenance therapy is unclear. The aim of this study was to determine if maintenance therapy with low-dose IVIg improves clinical outcomes and may be used as a steroid-sparing agent in myasthenia gravis (MG). Long-term treatment response to IVIg was assessed by improvement in the Myasthenia Gravis Foundation of America (MGFA) clinical classification scale as the primary endpoint. Low-dose IVIg

Optimal duration of fertility-sparing hormonal treatment for early-stage endometrioid endometrial cancer

To analyze oncologic outcomes of long-term fertility-sparing treatment (FST) in patients with early-stage endometrial cancer. Patients undergoing FST for presumed stage IA, grade 1 EC between 2005 and 2008 were retrospectively analyzed. Patients not achieving CR and not showing PD at 6 months of FST could continue further FST. If disease progression is excluded, ​15 months of FST can be considered as the cutoff for the optimal FST duration.

Heart Failure Hospitalization Risk associated with Iron Status in Veterans with CKD

Iron dysmetabolism potentially contributes to heart failure. The relationship between iron and heart failure has not been well characterized in CKD. Higher iron status was associated with lower hospitalization risks.

Stereotactic Body Radiation Therapy for Operable Early-Stage Lung Cancer: Findings From the NRG Oncology RTOG 0618 Trial

SBRT has become a standard treatment for patients with medically inoperable early-stage lung cancer. The effectiveness in patients medically suitable for surgery is unclear. The S BRT appears to be associated with a high rate of primary tumor control, low treatment-related morbidity, and infrequent occurrence of cancer recurrence.

Recurrence of severe maternal morbidity: A population‐based cohort analysis of California women

Severe maternal morbidity has increased in the U.S. by 45% in the last decade. To determine whether women who have SMM in a first pregnancy are at increased risk. A population-based study using linked vital statistics and hospital discharge records from 1997 to 2012. Women who have SMM in their first pregnancy are at a sixfold increased risk of having another baby.

Training and transfer of colonoscopy skills: a multinational, randomized, blinded, controlled trial of simulator versus bedside training

Simulator training significantly improved performance on simulated cases compared with patient-based training. Subjects had higher completion rates and shorter completion times.

Efficacy and safety of certolizumab pegol in an unselected crohn's disease population: 26-week data of the FACTS II survey

Certolizumab pegol (Cimzia, CZP) was approved for the treatment of Crohn's disease (CD) patients in 2007 in Switzerland. This prospective phase IV study aimed to evaluate the efficacy and safety.

Randomized phase III trial in elderly patients comparing LV5FU2 with or without irinotecan for first-line treatment of metastatic colorectal cancer (FFCD 2001-02)

Metastatic colorectal cancer (mCRC) frequently occurs in elderly patients. The benefit of first-line CT intensification remains an issue. Four arms were randomly assigned to receive 5-FU (5-fluorouracil)-based CT.

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