COVID-19-related medical research: a meta-research and critical appraisal

Since the start of the outbreak, a large number of COVID-19-related papers have been published. Concerns about the risk of expedited science have been raised. Out of 11,452 publications identified, among which 7468 were peer-reviewed articles. 4190 publications (56.1%) did not include any data or analytics.

SARS-CoV-2 infection and adverse events in patients with cancer receiving immune checkpoint inhibitors: an observational prospective study

Safety of targeted therapies (TTs), chemotherapy (CT) or immune checkpoint inhibitors (ICIs) therapy is still unknown. Mortality of SARS-CoV-2-positive patients was statistically significantly higher. Serious adverse events (SAEs) were more frequent in those treated with ICIs and CT.

Metabolic associated fatty liver disease increases the severity of COVID-19: A meta-analysis

To explore the association between MAFLD and the severity of COVID-19 by meta-analysis.

TSP-based PCR for rapid identification of L and S type strains of SARS-CoV-2

Study also analyzed 18,221 whole genome sequences (WGS) available up to April 2020 to know the prevalence of L and S type strains. The study did not detect any significant recombination events between closely related coronavirus and SARS-CoV-2.

A Comparative Systematic Review of COVID-19 and Influenza

SARS-CoV-2 and influenza virus share similarities such as clinical features and outcome, laboratory, and radiological findings. Comorbidities such as cardiovascular diseases, diabetes, and obesity were significantly higher in COVID-19 patients, while pulmonary diseases and immunocompromised conditions were significantly more common in influenza patients.

Breakthrough healthcare technologies in the COVID-19 era: a unique opportunity for cardiovascular practitioners and patients

The COVID-19 pandemic has reduced timely hospital admissions for ST-elevation myocardial infarction in Europe and the USA. We searched biomedical databases, websites and social media for smartcare approaches suitable for application in the pandemic.

Evidence of Severe Acute Respiratory Syndrome Coronavirus 2 Replication and Tropism in the Lungs, Airways, and Vascular Endothelium of Patients With Fatal Coronavirus Disease 2019: An Autopsy Case Series

The coronavirus disease 2019 (COVID-19) pandemic continues to produce substantial morbidity and mortality. This work provides important insights into pathogenesis and mechanisms of severe outcomes.

How does SARS-CoV-2 targets the elderly patients? A review on potential mechanisms increasing disease severity

In this narrative review, we address potential mechanisms regarding viral transmission, physical reserve and the immune system. The highest mortality is found between 80 and 89 years old in patients with SARS-CoV-2. In patients with cardiovascular comorbidity, increasing disease severity seems to aggravate this pro-inflammatory tendency.

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