Second-line chemotherapy for advanced biliary tract cancer after failure of the gemcitabine-platinum combination: A large multicenter study by the Association des Gastro-Entérologues Oncologues

Few data are available on second-line chemotherapy (CT2) for advanced biliary tract cancer (ABTC) CT2 might provide disease control for selected patients with ABTC after the failure of gemcitabine-platinum, but the prognosis remains poor

Lanreotide Autogel in the Treatment of Idiopathic Refractory Diarrhea: Results of an Exploratory, Controlled, Before and After, Open-label, Multicenter, Prospective Clinical Trial

Chronic idiopathic diarrhea is the passage of loose stools >3 times daily, or a stool weight >200 g/d. Patients refractory to standard anti-diarrhetic have limited treatment options. Somatostatin analogs have the ability to reduce gastrointestinal secretions and motility.

Implications of Infliximab Treatment Failure and Influence of Personalized Treatment on Patient-reported Health-related Quality of Life and Productivity Outcomes in Crohn's Disease

59 Crohn's disease patients with IFX treatment failure were randomized to an intensified IFX regimen or personalized treatment. Health-related quality of life and productivity were assessed at treatment failure and after 4, 8, 12 and 20 weeks.

Changes in serum trough levels of infliximab during treatment intensification but not in anti-infliximab antibody detection are associated with clinical outcomes after therapeutic failure in Crohn's disease

Intensification of the infliximab (IFX) regimen is recommended if the treatment effect is inadequate. The rationale for this is not well defined as the underlying mechanisms vary.

Physical Function and Spinal Mobility Remain Stable Despite Radiographic Spinal Progression in Patients with Ankylosing Spondylitis Treated with TNF-α Inhibitors for Up to 10 Years

Patients with ankylosing spondylitis were treated with tumor necrosis factor-alpha (TNF-α) inhibitors for up to 10 years. Spinal radiographs were scored according to the modified Stoke Ankyl losing Spondylitis Spine Score.

Benefit of "transparent soft-short-hood on the scope" for colonoscopy among experienced gastroenterologists and gastroenterologist trainee: a randomized, controlled trial

Transparent soft short hoods can be attached to the tip of the colonoscope tip to shorten the colonoscopy process. The study found significant shortening of the cecal intubation time in both the experienced endoscopist and gastroenterologist trainee groups

Assessment of still and moving images in the diagnosis of gastric lesions using magnifying narrow-band imaging in a prospective multicenter trial

Magnifying narrow-band imaging (M-NBI) is more accurate than white-light imaging for diagnosing small gastric cancers. Thirty-four endoscopists from ten different Japanese institutions participated in the prospective multicenter cohort study.

Effects of simulation versus traditional tutorial-based training on physiologic stress levels among clinicians: a pilot study

Emotionality and heightened anxiety during medical simulation encounters have been hypothesized to contribute to improved cognition and learning. The overall stress "dose-response curve" of experiential learning remains unclear.

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