Cervical cancer risk and screening among women seeking assistance with basic needs

In the U.S., more than half of cervical cancers occur in women who are inadequately screened. This study aimed to evaluate the need for cervical cancer screening among women. Women in the navigator group reported higher rates of contacting the test referral than those exposed to verbal referral only. Health navigators triple the likelihood that women will make contact with Papanicolaou test services.

Acute kidney injury in pediatric non-traumatic rhabdomyolysis

The study aimed to determine the prevalence of acute kidney injury in pediatric non-traumatic rhabdomyolysis. The primary outcome was the occurrence of AKI within the first 7 days of admission. AKI was relatively rare in children with viral myositis (2.6%)

Effect of pre-exposure use of hydroxychloroquine on COVID-19 mortality: a population-based cohort study in patients with rheumatoid arthritis or systemic lupus erythematosus using the OpenSAFELY platform

Hydroxychloroquine has been shown to inhibit entry of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) into epithelial cells in vitro. Clinical studies found no evidence of reduced mortality when treating patients with COVID-19. After accounting for age, sex, ethnicity, use of other immunosuppressive drugs, and geographical region, no association with COVID-19 mortality was observed.

Molecular and serological characterization of SARS-CoV-2 infection among COVID-19 patients

More than 80% of COVID-19 patients exhibit mild or moderate symptoms. Respiratory SARS-CoV-2 RNA was detectable in 58.0% (58/100) patients upon admission and lasted for a median of 13 days post-onset

Evaluation of potential anti-RNA-dependent RNA polymerase (RdRP) drugs against the newly emerged model of COVID-19 RdRP using computational methods

Despite all the efforts to treat COVID-19, no particular cure has been found for this virus. As a vital component in the life cycle of coronaviruses, RNA-dependent RNA polymerase (RdRP) can be a critical target for antiviral drugs.

A single center cohort of 40 severe COVID-19 patients who were treated with convalescent plasma

Convalescent plasma (CP) was previously used successfully to treat SARS-CoV-1 and MERS infections. Nine out of 10 patients who have received CP outside ICU have totally recovered from COVID-19 at a median of 9 days.

Quantifying the potential value of antigen-detection rapid diagnostic tests for COVID-19: a modelling analysis

In a hospital setting, an Ag-RDT-led strategy would avert more deaths than a NAT-based strategy, and at a lower cost per death averted. We evaluated the health system using decision analysis. We performed a muttering sensitivity analysis to all of these parameters

Detection of SARS-CoV-2 in fecal samples with different pretreatment methods and PCR kits

Fecal sample testing with real-time RT-PCR is highly recommended as a routine test for SARS-CoV-2 infection. 39.29% detection rate in the fecal sample by DAAN was obtained, while Bio-germ was 40.48%, Sansure 34.52% and GeneoDx 33.33%. The former three kits had no significant difference

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