An open-label prospective randomized multicenter study of intensive versus weekly granulocyte and monocyte apheresis in active crohn's disease

GMA has shown efficacy in patients with active Crohn's disease (CD) However, with routine weekly therapy, it may take several weeks to achieve remission. This study was performed to assess clinical efficacy and safety of intensive GMA in patients

Endoscopic suturing for transoral outlet reduction increases weight loss after Roux-en-Y gastric bypass surgery

Weight regain or insufficient loss after Roux-en-Y gastric bypass (RYGB) is common. This is partially attributable to dilatation of the gastrojejunostomy (GJ), which diminishes the restrictive capacity of RYGB

Geriatric factors analyses from FFCD 2001-02 phase III study of first-line chemotherapy for elderly metastatic colorectal cancer patients

Elderly patients (75+) with previously untreated mCRC were randomly assigned to receive infusional 5-fluorouracil-based chemotherapy. Normal IADL was independently associated with better OS. The benefit of doublet chemotherapy on PFS differed in subgroups of patients with the unresected primary tumor, leucocytes >11,000 mm3, and carcinoembryonic antigen >2N.

An open-label prospective randomized multicenter study of intensive versus weekly granulocyte and monocyte apheresis in active crohn's disease

GMA has shown efficacy in patients with active Crohn's disease (CD) However, with routine weekly therapy, it may take several weeks to achieve remission.

A randomized clinical trial of mesalazine suppository: the usefulness and problems of central review of evaluations of colonic mucosal findings

A double-blind, placebo-controlled, parallel-group trial was performed for 4weeks, which involved continuous administration of a 1-g mesalazine suppository to 129 patients with mild to moderate ulcerative colitis and active rectal inflammatory findings. The endoscopic remission induction rate from the attending physicians' evaluations was 82.8% and 31.1% in the placebo group.

Single-stage endoscopic treatment for mild to moderate acute cholangitis associated with choledocholithiasis: a multicenter, non-randomized, open-label and exploratory clinical trial

Two-stage treatment involving stone removal after drainage is recommended for mild to moderate acute cholangitis associated with choledocholithiasis

Evaluation of formal feedback on endoscopic competence among trainees: the EFFECT trial

The study aimed to characterize the impact of feedback on colonoscopy performance among gastroenterology (GI) trainees. After feedback, caecal intubation improved by 10.5% in the feedback group and declined by 6.1% in the control group. polyp detection improved by 5.1%.

Algorithm-based management of patients with gastrointestinal symptoms in patients after pelvic radiation treatment (ORBIT): a randomised controlled trial

Chronic gastrointestinal symptoms after pelvic radiotherapy are common and affect patients' quality of life. Nurse-led algorithm-based treatment was found to be more effective than gastroenterologist-led or booklet-based care.

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